Vildagliptinboronic acid
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid
CAS: 852331-49-8
Molecular Formula: C16H27BN2O4
Vildagliptinboronic acid - Names and Identifiers
| Name | [(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid |
| Synonyms | Vildagliptinboronic acid Vildagliptin-Boronic Acid [(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2... [(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid [(2R)-1-[2-[(1-hydroxy-2-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid [(2R)-1-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinyl]boronic acid Boronic acid, B-[(2R)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinyl]- |
| CAS | 852331-49-8 |
| InChI | InChI=1/C16H27BN2O4/c20-14(19-3-1-2-13(19)17(22)23)9-18-15-5-11-4-12(6-15)8-16(21,7-11)10-15/h11-13,18,21-23H,1-10H2/t11?,12?,13-,15?,16?/m0/s1 |
Vildagliptinboronic acid - Physico-chemical Properties
| Molecular Formula | C16H27BN2O4 |
| Molar Mass | 322.21 |
| Density | 1.31 |
| Boling Point | 566.005°C at 760 mmHg |
| Flash Point | 296.11°C |
| Vapor Presure | 0mmHg at 25°C |
| Refractive Index | 1.598 |
Vildagliptinboronic acid - Introduction
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid([(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid) is an organic compound. The following is a detailed description of its nature, use, formulation and some safety information:
Nature:
-Molecular formula: C14H22BNO4
-Molecular weight: 279.14g/mol
-Appearance: solid powder
-melting point: about 185-190 ℃
-Solubility: It is easily soluble in common organic solvents (such as dimethyl sulfoxide and dimethylformamide) and has high solubility.
Use:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid is an organoboron compound with a wide range of applications in medicinal chemistry and biomedical research. It is commonly used as a synthetic intermediate in drug development and can be used to prepare various active drug molecules. In addition, it can also be used in the research and synthesis of boronic acid compounds.
Preparation Method:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid can be synthesized by the following steps:
1. The pyrrolidine is reacted with 3-hydroxyadamantanamine by a substitution reaction catalyzed by zirconium to obtain (3-hydroxy-1-adamantyl) pyrrolidine.
2. (3-hydroxy-1-adamantyl) pyrrolidine is reacted with acetyl chloride to generate a substrate.
3. The further reaction of the substrate with boric acid produces the final product-[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid.
Safety Information:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid has high safety, but it is still necessary to take safety measures in conventional chemical laboratories. Avoid contact with skin and eyes and make sure to operate in well-ventilated conditions. Detailed safety information can be found in the relevant chemical safety data sheets.
Nature:
-Molecular formula: C14H22BNO4
-Molecular weight: 279.14g/mol
-Appearance: solid powder
-melting point: about 185-190 ℃
-Solubility: It is easily soluble in common organic solvents (such as dimethyl sulfoxide and dimethylformamide) and has high solubility.
Use:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid is an organoboron compound with a wide range of applications in medicinal chemistry and biomedical research. It is commonly used as a synthetic intermediate in drug development and can be used to prepare various active drug molecules. In addition, it can also be used in the research and synthesis of boronic acid compounds.
Preparation Method:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid can be synthesized by the following steps:
1. The pyrrolidine is reacted with 3-hydroxyadamantanamine by a substitution reaction catalyzed by zirconium to obtain (3-hydroxy-1-adamantyl) pyrrolidine.
2. (3-hydroxy-1-adamantyl) pyrrolidine is reacted with acetyl chloride to generate a substrate.
3. The further reaction of the substrate with boric acid produces the final product-[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid.
Safety Information:
[(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidin-2-yl]boronic acid has high safety, but it is still necessary to take safety measures in conventional chemical laboratories. Avoid contact with skin and eyes and make sure to operate in well-ventilated conditions. Detailed safety information can be found in the relevant chemical safety data sheets.
Last Update：2024-04-09 20:52:54
