WARANGALONE
Warangalone
CAS: 4449-55-2
Molecular Formula: C25H24O5
WARANGALONE - Names and Identifiers
WARANGALONE - Physico-chemical Properties
| Molecular Formula | C25H24O5 |
| Molar Mass | 404.46 |
| Density | 1.258±0.06 g/cm3(Predicted) |
| Melting Point | 164-165 °C |
| Boling Point | 627.0±55.0 °C(Predicted) |
| pKa | 6.39±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| Use | Protein kinase A inhibitor, anti-inflammatory agent |
| In vitro study | Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells. |
WARANGALONE - Reference
| Reference Show more | 1. [IF=5.682] Lianzhi Mao et al."PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells."Aging-Us. 2021 May 15; 13(9): 12955–12972 |
WARANGALONE - Reference Information
| biological activity | Warangalone is an antimalarial compound that can inhibit the growth of 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) parasites with IC50 values of 4.8 μg/mL and 3.7 μg/mL respectively. Warangalone can also inhibit the cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 value of 3.5 μM. |
| target | IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1) IC50: 3.5 μM (cAK) |
| in vitro study | Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μ m. when HL-60 cells are exposed to Warangalone (30 μ m) for 24 h, warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. a time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells. |
Last Update：2024-04-09 20:52:54
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Product Name: Warangalone Visit Supplier Webpage Request for quotationCAS: 4449-55-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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