WYE 354
WYE-354
CAS: 1062169-56-5
Molecular Formula: C24H29N7O5
WYE 354 - Names and Identifiers
WYE 354 - Physico-chemical Properties
| Molecular Formula | C24H29N7O5 |
| Molar Mass | 495.53 |
| Density | 1.46 |
| pKa | 13.42±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | In the DELFIA measuring His6-S6K1 T389 phosphorylation, WYE-354 inhibits recombinant mTOR enzyme with an IC 50 of 5 nM. Cell viability is analyzed by MTS assay. G-415 and TGBC-2TKB cell lines are treated with increasing concentrations of WYE-354 (0.1, 1, 5 and 10 μM) for 24, 48, and 72 hours. WYE-354 significantly reduces cell viability starting at a 1 μM concentration after a 24 hours exposure, in both studied cell lines (P<0.001). A decrease in cell viability is not observed at a dose of 100 nM, except for the TGBC-2TKB cell line after 72 hours of treatment. |
| In vivo study | The effect of Rapamycin and WYE-354 on tumor growth is evaluated in xenograft GBC tumor models. 2×10 6 or 5×10 6 cells of G-415 or TGBC2TKB, respectively, are xenotransplanted into NOD-SCID mice subcutaneously. When tumors reach an average volume of 100 mm 3 , the mice are treated either with Rapamycin or WYE354. Rapamycin is administered i.p. at a concentration of 10 mg/kg, daily for 5 days per week for 3 weeks, while WYE-354 is administrated at a daily i.p. dose of 50 mg/kg for 5 days. Mice are sacrificed 30 days after the initiation of the treatments and an autopsy is performed that include removal of the entire tumor area. Mice treated with WYE-354 exhibit 68.6% and 52.4% reduction in average tumor size (P<0.01; P<0.01), as well as 82.9% and 45.5% (P<0.01; ns) reduction in tumor weight, respectively. |
WYE 354 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.018 ml | 10.09 ml | 20.18 ml |
| 5 mM | 0.404 ml | 2.018 ml | 4.036 ml |
| 10 mM | 0.202 ml | 1.009 ml | 2.018 ml |
| 5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
Last Update：2024-01-02 23:10:35
WYE 354 - Introduction
WYE-354 is a chemical substance also known as WYE-354 alkali salt. The following is a description of the nature, use, formulation and safety information of WYE-354:
Nature:
WYE-354 is a white or off-white crystalline solid. It has a high melting point and relative molecular mass, soluble in a certain range of organic solvents, such as dimethyl sulfoxide, dimethylformamide and so on. Its structure and chemical properties are often related to acetamide compounds.
Use:
WYE-354 is primarily used as a PARP (polymerase-adenosine diphosphate ribose) enzyme inhibitor. PARP plays an important role in DNA repair, and WYE-354 can inhibit the activity of the enzyme. Therefore, WYE-354 is widely used in cancer treatment research, especially in the field of treatment related to tumor cell DNA damage.
Preparation Method:
The formulation of WYE-354 has not yet been publicly disclosed and is a commercial secret. In general, it is synthesized by organic synthetic chemical methods.
Safety Information:
In the process of handling WYE-354, you need to pay attention to the following safety precautions: When using, you should wear protective gloves, protective glasses and protective masks to avoid direct contact with the body and skin. Avoid inhaling dust or gases from this compound and ensure that the operating area is well ventilated. In case of inadvertent inhalation or exposure to the substance, consult a doctor immediately with detailed information. Storage should be kept away from fire and oxidant, and keep sealed, avoid mixing with other chemicals.
Nature:
WYE-354 is a white or off-white crystalline solid. It has a high melting point and relative molecular mass, soluble in a certain range of organic solvents, such as dimethyl sulfoxide, dimethylformamide and so on. Its structure and chemical properties are often related to acetamide compounds.
Use:
WYE-354 is primarily used as a PARP (polymerase-adenosine diphosphate ribose) enzyme inhibitor. PARP plays an important role in DNA repair, and WYE-354 can inhibit the activity of the enzyme. Therefore, WYE-354 is widely used in cancer treatment research, especially in the field of treatment related to tumor cell DNA damage.
Preparation Method:
The formulation of WYE-354 has not yet been publicly disclosed and is a commercial secret. In general, it is synthesized by organic synthetic chemical methods.
Safety Information:
In the process of handling WYE-354, you need to pay attention to the following safety precautions: When using, you should wear protective gloves, protective glasses and protective masks to avoid direct contact with the body and skin. Avoid inhaling dust or gases from this compound and ensure that the operating area is well ventilated. In case of inadvertent inhalation or exposure to the substance, consult a doctor immediately with detailed information. Storage should be kept away from fire and oxidant, and keep sealed, avoid mixing with other chemicals.
Last Update：2024-04-09 20:48:19
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CAS: 1062169-56-5
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CAS: 1062169-56-5
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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Product Name: WYE-354 Visit Supplier Webpage Request for quotation
CAS: 1062169-56-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1062169-56-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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