White Mulberry Root-bark Extract
CAS: Cortex Mori
Molecular Formula:
White Mulberry Root-bark Extract - Names and Identifiers
White Mulberry Root-bark Extract - Physico-chemical Properties
| Storage Condition | Room Temprature |
White Mulberry Root-bark Extract - Usage and dosage
Open Data Unverified Data
oral administration: decoction, 9~15g; Or into pills, powder. External use: appropriate amount, mash juice; Or fry water; Or boil paste.
Last Update：2024-04-09 19:43:38
White Mulberry Root-bark Extract - Functional Indications
Open Data Unverified Data
Xiefei, relieving asthma, relieving swelling. It is used for lung heat, wheezing and cough, edema and full urine, and swollen skin.
Last Update：2024-04-09 19:43:38
White Mulberry Root-bark Extract - Taboo
Open Data Unverified Data
cold lung without fire and cold cough forbidden clothing.
Last Update：2024-04-09 19:43:38
White Mulberry Root-bark Extract - Efficacy and role
Open Data Unverified Data
Cortex Mori has the efficacy of purging lung, relieving asthma, relieving swelling, and treating lung heat, cough, edema, etc.
Morus Alba is the dry root bark of Mulberry, a plant in the Moraceae family. It is sweet in taste and cold in nature. It belongs to the lung and kidney. It has the effects of purging lung, relieving asthma, and relieving swelling. Clinically, it can be used to treat lung heat cough, phlegm and asthma cough, edema, adverse urination and other diseases. Mulberry bark is generally taken orally, decocted or into pills and powder. Sangbaipi is cold and cold, and is good at relieving lung qi. It is a good medicine for treating lung heat, cough and asthma.
Sangbai bark is bitter and cold, which can clear lung fever, reduce lung fire, relieve water and reduce swelling. Clinically, it can be used to treat lung heat cough, phlegm and cough, edema and less urine. Mulberry bark bitter cold, easy to hurt the spleen and stomach, where the spleen and stomach deficiency cold diarrhea. If you need to use mulberry bark to treat diseases, it should be carried out under the guidance of a doctor. Do not use drugs without authorization to avoid adverse consequences.
Last Update：2024-04-09 19:43:38
White Mulberry Root-bark Extract - Reference Information
| plant extract | Morus alba extract is derived from the dried root bark of Morus alba L, for the "Chinese Pharmacopoeia" collection of varieties. Mainly produced in Anhui, Henan, Zhejiang, Jiangsu, Hunan and other places. She has sweet and cold nature. Into lung and spleen. Efficacy: purging lung and relieving asthma. For hot cough, vomiting blood, edema, beriberi, urine adverse. It contains chemical constituents such as umbelliferide, scopoletin and Phloretin. |
| Overview | Common name: cortex Mori extract : white Mulberry Root-Bark Extract Other Name: Mulberry Root White Bark, Mulberry Root Bark, Mulberry Bark, White Mulberry Bark Category: Phlegm-resolving antitussive and Antiasthmatic drugs character: brownish yellow powder medicinal parts: root bark Source: Dry root bark of Moraceae Mulberry, which is removed from the corns, can be collected and excavated in spring and winter, and then soil is washed, the outer yellow thick skin was scraped off, cut open longitudinally with a knife, and tapped with a wooden hammer to separate the skin from the wood. The white skin was peeled off, dried in the sun, and ligated into a small bundle. |
| Chemical composition | containing umbelliferal flower lactone, doxycycline and flavonoids, including mulberry root bark, Mulberry, cyclomorphine, cyclomorphene, etc. It also contains hypotensive components similar to acetylcholine, and contains tannins and mucins. |
| extraction method | preparation process of light-based flavonoids in cortex Mori preparation of active components from cortex Mori includes two aspects: extraction and purification. The main extraction method of active components in cortex Mori is to extract with solvent at room temperature for a long time, including two processes, first with n-hexane or petroleum ether degreasing; And then with organic solvent to extract, the organic solvents used in this step are mainly methanol, ethanol, acetone and ethyl acetate. The extract obtained by solvent extraction was further refined to obtain a pure product. The commonly used methods include column chromatography, preparative Thin layer chromatography, alkali extraction acid precipitation, crystallization and other methods. These methods are often used in combination. FIG. 1 shows the production process of Mulberry ketone C and D. |
| physical and chemical identification | 1. Thin layer chromatography take mulberry bark powder 1.09, add 95% ethanol 90ml, set water bath reflux extraction lhr, while hot filtration, the filtrate is evaporated to dryness on water bath, the residue was dissolved by adding ethyl acetate sml and filtered. The filtrate spl was extracted and applied to the activated (110oC,30min) silica gel G thin-layer plate, using chloroform: Methanol (7.5:2.5) as the developing solvent, and spread up for about 15cm, spray with 5% sodium hydroxide solution. Inspection under UV lamp (254lun), with one yellow fluorescent spot at Rf value of 0.64, 0.36 and 0.15 respectively, and one bright blue fluorescent spot at Rf value of 0.60; the mulberry bark has a yellow fluorescent spot at the Rf value of 0.55, a blue-purple fluorescent spot at each of 0.62 and 0.26, and a bright blue spot at each of 0.58 and 0.18. 2. Identification by UV spectrum take 0.59 of cortex Mori powder, add 100ml of ethanol, pack, shake for 10 minutes, place it at room temperature for 12hr, and filter it, the filtrate was diluted with ethanol to give a sample at a concentration of 1 mg/ml. With ethanol as the blank, Uv 210 (Shimadzu, Japan) Uv analyzer on the determination of ultraviolet absorption spectrum (200 ~ 4OOIun). The results showed that the Broussonetia papyrifera had a maximum absorption at 226, 282nm respectively; The spiny Mulberry had a maximum absorption at 224, 263, 284, 324nm respectively; The mulberry bark had a maximum absorption at 226, 275, there is a maximum absorption at 304nm. FIG. 2 is a thin layer chromatogram and an ultraviolet absorption spectrum. |
| pharmacological action | Chinese herbal medicine uses the dried root bark of Moraceae plant mulberry. The medicinal material was flat and slightly bitter in taste. It has the following pharmacological effects: The water decoction of cortex Mori and a variety of soluble enzyme extracts have the effects of lowering blood pressure, sedation, stability, anticonvulsant and cooling. 100% decoction of Staphylococcus aureus, Salmonella Typhi, shigella flexneri have inhibitory effect, no inhibitory effect on Mycobacterium tuberculosis; Mild antitussive effect. In addition, cortex Mori decoction has diuretic and catharsis effect. The methanol extract of cortex Mori has hypoglycemic effect. Anti-Cancer Pharmacology 1. In animal experiments, the inhibition rate of hot water extract from cortex Mori on ascites sarcoma S180 in mice was 51.8%. In vitro test, the hot water extract on JTC-26 inhibition rate was 70% ~ 90%. Morin is a flavonoid derived from the bark and stem of Moraceae. Morin has a photosensitive killing effect on ascites type liver cancer cells (AH), and has a significant inhibitory effect on the DNA synthesis of liver cancer cells, the enhancement of the irradiation time is prolonged. Under the condition of avoiding light, Morin also has the ability to kill cancer cells, but it is far lower than that of the Light Group. The killing effect of Morin on liver cancer cells is permanent. |
| indications | cold, sweet. Qingfei huatan, Qi-lowering and asthma-relieving, diuresis and detumescence. The patient is mainly for cough and asthma due to lung heat, cough and cough against asthma due to water-drinking, often used with Digu skin, japonica rice and licorice; For treatment of Feng Shui, skin water edema and other disadvantageous urination. Now commonly used in the treatment of acute bronchitis, pleurisy, diabetes, etc., can also be used to treat a variety of cancer. |
| safety and toxicology evaluation | cortex Mori was repeatedly treated with petroleum ether, ethanol, acetic anhydride, water, acetic acid, ethyl ester, etc, the resulting yellow powder was injected intravenously into mice with an LD50 of 32.7mg/kg. No death was induced by gavage or intraperitoneal injection of 10 g/kg or intravenous injection of 5 g/kg of n-butanol extract or water extract. Alcohol extract no matter a large dose or multiple small dose administration, the experimental animals were not found adverse effects, it is considered that the drug toxicity is small. |
Last Update：2024-04-09 21:21:28
Supplier List
Product Name: Honey mulberry white skin Visit Supplier Webpage Request for quotation
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Honey mulberry white skin Visit Supplier Webpage Request for quotation
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History