alovudine
3'-deoxy-3'-fluorothymidine
CAS: 25526-93-6
Molecular Formula: C10H13FN2O4
alovudine - Names and Identifiers
| Name | 3'-deoxy-3'-fluorothymidine |
| Synonyms | FLT MIV 310 alovudine CL 184824 NSC 140025 3'-Fluorothymidine 3'-Fluoro-thymidine 3'-Fluorodeoxythymidine 3'-deoxy-3'-fluoro-thymidin 3'-fluoro-3'-deoxythymidine 3'-deoxy-3'-fluorothymidine THYMIDINE, 3'-DEOXY-3'-FLUORO- Thymidine, 3'-deoxy-3'-fluoro- 3'-fluoro-2',3'-dideoxythymidine 1-(3'-Deoxy-3'-fluoro--D-pentofuranosyl)thymine 1-(3-Fluoro-2,3-dideoxy-β-D-ribofuranosyl)thymine 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine 1-(2,3-dideoxy-3-fluoropentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-[(3xi)-2,3-dideoxy-3-fluoro-beta-D-glycero-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione |
| CAS | 25526-93-6 |
| InChI | InChI=1/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6?,7-,8-/m1/s1 |
| InChIKey | UXCAQJAQSWSNPQ-XLPZGREQSA-N |
alovudine - Physico-chemical Properties
| Molecular Formula | C10H13FN2O4 |
| Molar Mass | 244.22 |
| Density | 1.2866 (estimate) |
| Melting Point | 176-178°C(lit.) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | buffered aqueous solution |
| Color | White to Beige |
| pKa | 9.55±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.565 |
alovudine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | XP2073000 |
| HS Code | 29349990 |
alovudine - Reference Information
| biological activity | 3 '-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is an effective inhibitor of polymerase gamma and reverse transcriptase that can be used to treat HIV infection. 3 '-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis and can be used as a biomarker for early response to pancreatic cancer chemotherapy. |
| Target | Value |
| Use | Antiviral reagents with application prospects, the activity is similar to other 3 ′-deoxy-3 ′-substituted thymidine. |
Last Update：2024-04-09 15:16:49
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