Name | 2-(4-Chlorophenoxy)-2-methylpropionic acid |
Synonyms | alfibrate Atherolip Alluminum ALUFIBRATE Clofibric acid ALUMINUM CLOFIBRATE Aluminum Clofibrate aluminium clofibrate 4-Chlorophenoxy-iso-butyrcc Acid 2-(4-Chlorophenoxy)isobutyric acid 2-(4-chlorophenoxy)-2-methylpropanoate 2-(4-Chlorophenoxy)-2-methylpropionic acid 2-(p-Chlorophenoxy)-2-methylpropionic acid 3-(4-chlorophenoxy)-2-methylpropanoic acid 2-(4-chlorophenoxy)-2-methylpropanoic acid R(+)-2-(4-chloro-2-methyl phenoxy) propionic acid Bis[2-(p-chlorophenoxy)-2-methylpropionic acid]hydroxyaluminum salt |
CAS | 882-09-7 24818-79-9 |
EINECS | 246-477-0 |
InChI | InChI=1/2C10H11ClO3.Al.H2O/c2*1-10(2,9(12)13)14-8-5-3-7(11)4-6-8;;/h2*3-6H,1-2H3,(H,12,13);;1H2/q;;+3;/p-3/rC20H21AlCl2O7/c1-19(2,27-15-9-5-13(22)6-10-15)17(24)29-21(26)30-18(25)20(3,4)28-16-11-7-14(23)8-12-16/h5-12,26H,1-4H3 |
Molecular Formula | C20H20AlCl2O7 |
Molar Mass | 470.25 |
Melting Point | 120-123℃ |
Boling Point | 230°C |
Solubility | Soluble in water (partly), 1eq. NaOH (100 mM), methanol (50 mg/ml), chloroform, and eth |
Appearance | Pale yellow solid |
Storage Condition | 2-8℃ |
Sensitive | Easily absorbing moisture |
MDL | MFCD00004192 |
Use | For pharmaceutical intermediates of antoamine |
Safety Description | S24/25 - Avoid contact with skin and eyes. |
A crystalline solid having a melting point of 118 to 119 ° C. (120 to 122 ° C.).
obtained by condensation of p-chlorophenol. Add p-chlorophenol and acetone into the reaction kettle, add sodium hydroxide under stirring, add chloroform Dropwise at about 20 ℃, and react at 25~30 ℃, when the reaction changes from vigorous to mild, the mixture was heated to reflux for 3H, and acetone was recovered by distillation. Add water, heated to 70 ℃ to dissolve the solid, and hydrochloric acid neutralization to Ph 2~3, cooling precipitation of crystals, cooling to below 10 ℃, filtration, washing, drying to obtain this product.
pharmaceutical intermediates, used for antoamine, antoamine aluminum salt, antoamine malonate, etc.