benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate
Z-D-Pro-NH2
CAS: 62937-47-7
Molecular Formula: C13H16N2O3
benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate - Names and Identifiers
| Name | Z-D-Pro-NH2 |
| Synonyms | Z-D-Pro-NH2 Cbz-D-prolinaMide Cbz-D-prolinamide 1-CBZ-D-PROLINAMIDE (R)-2-CARBAMOYL-1-CBZ-PYRROLIDINE (R)-2-Carbamoyl-1-N-Cbz-pyrrolidine (R)-benzyl 2-carbamoylpyrrolidine-1-carboxylate benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 2-carbamoyl-1-pyrrolidinecarboxylic acid (phenylmethyl) ester Benzyloxycarbonyl-L-prolinamide, Carbobenzyloxy-L-prolinamide |
| CAS | 62937-47-7 |
| InChI | InChI=1/C13H16N2O3/c14-12(16)11-7-4-8-15(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,14,16)/t11-/m1/s1 |
benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C13H16N2O3 |
| Molar Mass | 248.28 |
| Density | 1.263±0.06 g/cm3(Predicted) |
| Melting Point | 90-95°C |
| Boling Point | 465.6±44.0 °C(Predicted) |
| Flash Point | 235.4°C |
| Vapor Presure | 7.61E-09mmHg at 25°C |
| pKa | 15.95±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.581 |
benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate - Introduction
Z-D-Pro-NH2(Z-D-Pro-NH2) is a prolinamide derivative with a special structure. The following is a description of its nature, use, preparation and safety information:
Nature:
- Z-D-Pro-NH2 is a colorless crystalline solid.
-It is stable in the air, but will decompose at high temperatures.
-Low solubility in water, can be dissolved in organic solvents.
Use:
- Z-D-Pro-NH2 is commonly used in the field of biomedical research as a protecting group for the amino acid prolinamide.
-It can be used for the synthesis of peptides, proteins and pharmaceutical intermediates.
-In drug development, Z-D-Pro-NH2 can also be used as a protecting group embedded in a large peptide chain.
Preparation Method:
-Usually p-aminobenzoic acid (Cbz-Cl) is used as raw material to react with D-proline to produce Z-D-Pro-NH2.
-The reaction is usually carried out at room temperature with the use of an organic solvent.
Safety Information:
- Z-D-Pro-NH2 are laboratory compounds, no significant harm to human health.
-Avoid contact with skin and eyes when using. For accidental contact, rinse with plenty of water and seek medical help.
-Store dry and sealed to avoid contact with oxidants.
Please note that the above information is for reference only. Please follow the relevant safety practices and laboratory instructions when using chemical laboratory supplies.
Nature:
- Z-D-Pro-NH2 is a colorless crystalline solid.
-It is stable in the air, but will decompose at high temperatures.
-Low solubility in water, can be dissolved in organic solvents.
Use:
- Z-D-Pro-NH2 is commonly used in the field of biomedical research as a protecting group for the amino acid prolinamide.
-It can be used for the synthesis of peptides, proteins and pharmaceutical intermediates.
-In drug development, Z-D-Pro-NH2 can also be used as a protecting group embedded in a large peptide chain.
Preparation Method:
-Usually p-aminobenzoic acid (Cbz-Cl) is used as raw material to react with D-proline to produce Z-D-Pro-NH2.
-The reaction is usually carried out at room temperature with the use of an organic solvent.
Safety Information:
- Z-D-Pro-NH2 are laboratory compounds, no significant harm to human health.
-Avoid contact with skin and eyes when using. For accidental contact, rinse with plenty of water and seek medical help.
-Store dry and sealed to avoid contact with oxidants.
Please note that the above information is for reference only. Please follow the relevant safety practices and laboratory instructions when using chemical laboratory supplies.
Last Update：2024-04-09 15:17:59
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CAS: 62937-47-7
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CAS: 62937-47-7
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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