biphenyl-4-yl chlorothioformate(biphenyl-4-yl chlorothioformate) is an organic compound with a molecular formula of C13H9ClOS and a relative molecular mass of 254.72. It is a light yellow liquid with a pungent odor at room temperature.
One of the main uses of biphenyl-4-yl chlorothioformate is as a functional group transfer reagent. It can react with functional groups containing active hydrogen atoms in organic compounds to convert the thiocarbonic acid group into a thioether group and simultaneously introduce a biphenyl ester group. This reagent is used in organic synthesis to prepare various thioether compounds, such as pharmaceutical intermediates, pesticides and other important intermediates in organic chemistry research.
The method of preparing biphenyl-4-yl chlorothioformate generally includes reacting thiocarbonic acid with p-benzidine to produce intermediate p-biphenyl disulfide, and then reacting with chloroformic acid to form the final product.
biphenyl-4-yl chlorothioformate need to pay attention to safety issues during storage and operation. It is an irritant substance that may cause irritation and discomfort when in contact with the skin, eyes, or respiratory tract. Therefore, suitable protective gloves, goggles and protective masks should be worn during operation to ensure good ventilation conditions. In addition, it should be stored in a cool, dry, dark place, away from fire and oxidant, avoid mixing with other chemicals.