carbazamidine hydrochloride

carbazamidine hydrochloride - Names and Identifiers

Name	Aminoguanidine Hydrochloride
Synonyms	amino-guanidinhydrochloride carbazamidine hydrochloride Aminoguanidine Hydrochloride Aminoguanadine hydrochloride 2-aminoguanidine hydrochloride carbazamidine monohydrochloride hydrazinecarboximidamidehydrochloride (diaminomethylidene)hydrazinium chloride Metformin Impurity 15(Aminoguanidine hydrochloride)
CAS	1937-19-5 16139-18-7
EINECS	217-707-7
InChI	InChI=1/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H

carbazamidine hydrochloride - Physico-chemical Properties

Molecular Formula	CH7ClN4
Molar Mass	110.54608
Melting Point	162-166°C(lit.)
Boling Point	261.4°C at 760 mmHg
Flash Point	111.9°C
Water Solubility	506.7g/L at 20℃
Solubility	Completely soluble in water
Vapor Presure	0Pa at 25℃
Appearance	White to white-like crystals
Color	White to off-white
Merck	13,440
BRN	3909606
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
MDL	MFCD00039074
In vivo study	Aminoguanidine can improve neonatal hypoxic-ischemic brain damage, and the time distribution of NO is related to the neuroprotective effect of aminoguanidine. AG exerts its neuroprotective effect by inhibiting NO produced by iNOS during post-hypoxia reoxygenation. The Half-Life of Aminoguanidine in the body is about 6-8 hours, and about 4.4 hours in people with normal renal function. Minoguanidine is also an inhibitor of the formation of advanced glycation end products. Treatment of adult rats with BSA modified by advanced glycation end products increased their cerebral infarct size, while Aminoguanidine attenuated this effect.

carbazamidine hydrochloride - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	ME8430000
FLUKA BRAND F CODES	10-21
HS Code	29280000

carbazamidine hydrochloride - Reference

Reference

1. [IF=6.057] Ying Wang et al."Enhancement effect of p-iodophenol on gold nanoparticle-catalyzed chemiluminescence and its applications in detection of thiols and guanidine."Talanta. 2018 May;182:523
2. [IF=2.776] Wenlu Li et al."Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress."Plos One. 2013 Sep;8(9):e76025
3. [IF=5.275] Remah Sobhy et al."The noncovalent conjugations of bovine serum albumin with three structurally different phytosterols exerted antiglycation effects: A study with AGEs-inhibition, multispectral, and docking investigations."Bioorg Chem. 2020 Jan;94:103478
4. [IF=6.576] Yingchun Jin et al."Characteristics of Mulberry Leaf Powder Enriched With γ-Aminobutyric Acid and Its Antioxidant Capacity as a Potential Functional Food Ingredient."Frontiers in Nutrition. 2022; 9: 900718

carbazamidine hydrochloride - Reference Information

LogP	-3.55 at 20℃
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Application	Aminoguanidine hydrochloride is a pharmaceutical intermediate and organic synthesis intermediate, which can be prepared from aminoguanidine carbonate and can be used in the preparation of daidzein derivatives and laboratory organic synthesis process.
preparation	preparation of aminoguanidine hydrochloride: weigh 9g of aminoguanidine carbonate and place it in a 250ml three-mouth flask, add 20ml of anhydrous ethanol, the solid is insoluble in anhydrous ethanol to form a suspension, add a mixture of 6ml of 30% concentrated hydrochloric acid and 10ml of anhydrous ethanol dropwise under room temperature stirring, until no bubbles are generated, and continue stirring and reaction at room temperature for 1 hour. Heat the resulting suspension to completely dissolve the solid, naturally drop to room temperature, move to the refrigerator, and leave it overnight to obtain a white rod-shaped crystal with a melting point of 166-167°C.
Biological activity	Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is an inhibitor of diamine oxidase and nitric oxide synthase. It reduces the level of advanced glycation end products (AGEs) by interacting with 3-deoxyglucosone.
Target	Value
category	toxic substances
toxicity classification	poisoning
acute toxicity	subcutaneous-rat LDL0: 2984 mg/kg
flammability hazard characteristics	combustible; combustion produces toxic nitrogen oxides and hydrogen chloride smoke
storage and transportation characteristics	warehouse ventilation and low temperature drying
fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water

Last Update：2024-04-09 19:05:10

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