diethyl dicarbonate
Diethyl pyrocarbonate
CAS: 1609-47-8
Molecular Formula: C6H10O5
diethyl dicarbonate - Names and Identifiers
| Name | Diethyl pyrocarbonate |
| Synonyms | DKD ethylpyrocarbonate Diethyl dicarbonate Ethyl pyrocarbonate Diethylpyrokarbonat Diethyl oxydiformate Diethyl pyrocarbonate Ethoxyformic anhydride diethylpyrocarbonicacid oxydi-formicacidiethylester diethylesterofpyrocarbonicacid ethyl (ethylperoxy)(oxo)acetate Pyrocarbonic acid diethyl ester Formic acid, oxydi-, diethyl ester |
| CAS | 1609-47-8 |
| EINECS | 216-542-8 |
| InChI | InChI=1/C6H10O5/c1-3-9-5(7)6(8)11-10-4-2/h3-4H2,1-2H3 |
| InChIKey | FFYPMLJYZAEMQB-UHFFFAOYSA-N |
diethyl dicarbonate - Physico-chemical Properties
| Molecular Formula | C6H10O5 |
| Molar Mass | 162.14 |
| Density | 1.12g/mLat 20°C |
| Melting Point | 69℃ |
| Boling Point | 93-94°C18mm Hg(lit.) |
| Flash Point | 157°F |
| Water Solubility | slow decomposition |
| Solubility | Soluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble |
| Vapor Presure | 1.31mmHg at 25°C |
| Appearance | Transparent liquid |
| Color | APHA: ≤20 |
| Merck | 14,7998 |
| BRN | 637031 |
| Storage Condition | 2-8°C |
| Stability | Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia. |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.398(lit.) |
| MDL | MFCD00009106 |
| Use | Modifying reagents for protein histidine and tyrosine. It is also a chemical modifier for RNase. It reacts with the imidazole ring of the active group histidine of RNase to inhibit RNase activity. |
diethyl dicarbonate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | 2810 |
| WGK Germany | 3 |
| RTECS | LQ9350000 |
| FLUKA BRAND F CODES | 4.4-9-21 |
| TSCA | Yes |
| HS Code | 29209085 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 850 mg/kg |
diethyl dicarbonate - Reference
| Reference Show more | 1. qu chongzheng, liu jiao. Effects of massage on TLR4 and MYD88 mRNA and protein in synovial membrane of knee osteoarthritis rats [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019,21(12):150-153. 2. Lin Zhenjia, Zhang Hui, Jie Yingtao, et al. Modified Trizol Method for Extracting Mouse Skin RNA [J]. Journal of Sun Yat-sen University (Medical Science Edition), 2020, 041(002):224-232. 3. Luo Zheng, Guo Yuanyuan, Chen Feiping, etc. research on phenylalanine enzyme, a key enzyme in inhibiting lignification of vegetable heart by high oxygen-modified atmosphere packaging [J]. food research and development, 2019, 40(08):36-40. 4. [IF = 4.219] Hu Zhang et al."the expression of macrophage migration inhibitory factor in the non-small cell lung cancer." Saudi j biol sci. 2020 jun; 27:1527 |
diethyl dicarbonate - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Diethyl pyrocarbonate is an organic ester compound, which can be used as a modification reagent for His and Tyr residues in proteins; used in dsDNA The durable probe for structural division reacts partially or completely with non-packed bases; used as an antibacterial additive, ribonuclease inhibitor, histidine residue modifier, and a reagent for converting imines into carbamates. diethyl pyrocarbonate can be used for RNA extraction in biological experiments. is an ester compound, which can be used as a modification reagent for histidine and tyrosine of diethyl pyrocarbonate protein, and is also a chemical modifier for RNase. It reacts with the imidazole ring of histidine, the active group of RNase, to inhibit RNase activity. |
Last Update：2024-04-10 22:29:15
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