Molecular Formula | C13H11N3O6S2 |
Molar Mass | 369.37 |
Density | 1.565±0.06 g/cm3(Predicted) |
pKa | 10.36±0.46(Predicted) |
Storage Condition | 2-8°C,干燥,密封 |
In vitro study | EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function. EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17. |
biological activity | EACC is a reversible autophagy inhibitor that blocks the autophagy flux. EACC selectively inhibits autophagosome-specific translocation of SNARE Stx17, thereby preventing fusion of Autophagosomes with lysosomes. |
Target | Autophagy |