ethyl 2-(4-cyanophenyl)acetate
ethyl 2-(4-cyanophenyl)acetate
CAS: 1528-41-2
Molecular Formula: C11H11NO2
ethyl 2-(4-cyanophenyl)acetate - Names and Identifiers
ethyl 2-(4-cyanophenyl)acetate - Physico-chemical Properties
| Molecular Formula | C11H11NO2 |
| Molar Mass | 189.21 |
| Density | 1.11 |
| Melting Point | 90-94°C |
| Boling Point | 305℃ |
| Flash Point | 141℃ |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD09953133 |
| Use | Application of 4-cyano-phenyl ethyl acetate is also called 2-(4-cyano phenyl) ethyl acetate, is an organic intermediate, can be prepared from 4-bromo-phenyl ethyl acetate and copper cyanide or zinc cyanide. |
ethyl 2-(4-cyanophenyl)acetate - Risk and Safety
| UN IDs | UN3439 |
| Hazard Class | 6.1 |
| Packing Group | III |
ethyl 2-(4-cyanophenyl)acetate - Upstream Downstream Industry
| Downstream Products | 4-AMINOMETHYLPHENYLACETIC ACID |
ethyl 2-(4-cyanophenyl)acetate - Preparation
Add ethyl 4-bromo-phenylacetate (423.7g) to the reactor under nitrogen protection, add NMP(2.1L) and CuCN(214g), heat to 200°C for reflux, stir at this temperature for 4 hours (analyze the product of this stage with IPC), cool to room temperature, add ethyl acetate (2.1L) and NH4Cl saturated aqueous solution (2.1L), filter, the organic layer is separated and cleaned with saturated NH4Cl(2.1L), the combined water layer is extracted with 1.2L ethyl acetate, the combined organic layer is cleaned with 1.2L saturated NaCl aqueous solution, layered, the organic layer is dried with NaSO4, concentrated, 200ml ethyl acetate and 2L PE are added, stirred for 30 minutes, filtered and dried to obtain the compound 4-cyano-ethyl phenylacetate (220g, yield 67.9%,IPC.
Last Update：2024-04-10 22:29:15
ethyl 2-(4-cyanophenyl)acetate - Reference Information
| Application | Ethyl 4-cyano-phenylacetate, also called 2-(4-cyanophenyl) ethyl acetate, is an organic intermediate, It can be prepared from ethyl 4-bromo-phenylacetate and cuprous cyanide or zinc cyanide. |
| Preparation | Ethyl 4-bromo-phenylacetate (423.7g) is added to the reactor under the protection of nitrogen, and NMP(2.1L) and CuCN(214g) are added, heated to 200°C for reflux, stirred at this temperature for 4 hours (analyze the product of this stage with IPC), and cooled to room temperature, add ethyl acetate (2.1L) and NH4Cl saturated aqueous solution (2.1L), filter, separate out the organic layer and clean with saturated NH4Cl(2.1L), merge the water layer and extract with 1.2L ethyl acetate, merge the organic layer and clean with 1.2L saturated NaCl aqueous solution, delaminate, dry the organic layer with NaSO4, concentrate, add 200ml of ethyl acetate and 2L PE, stir for 30 minutes, filter and dry to obtain compound 4-cyano-ethyl phenylacetate (220g, yield 67.9%,IPC retention time: 2.19min), brown solid. |
Last Update：2024-04-09 21:11:58
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Downstream Products for ethyl 2-(4-cyanophenyl)acetate