ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
Carbimazole
CAS: 22232-54-8
Molecular Formula: C7H10N2O2S
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Names and Identifiers
| Name | Carbimazole |
| Synonyms | CARBIMAZOLE Carbimazole Neo-Mercazole LABOTEST-BB LT00455569 1-Methyl-2-imidazolethiol ethyl carbamate ETHYL 3-METHYL-2-THIOMIDAZOLINE-1-CARBOXYLATE Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate ETHYL 3-METHYL-2-THIONOIMIDAZOLINE-1-CARBOXYLATE 1-ETHOXYCARBONYL-3-METHYL-2-THIOXO-4-IMIDAZOLINE Ethyl 3-methyl-2-thioxo-4-imidazoline-1-carboxylate 3-methyl-2-thionoimidazoline-1-carboxylic acid ethyl ester ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate |
| CAS | 22232-54-8 |
| EINECS | 244-854-4 |
| InChI | InChI=1/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3 |
| InChIKey | CFOYWRHIYXMDOT-UHFFFAOYSA-N |
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C7H10N2O2S |
| Molar Mass | 186.23 |
| Density | 1.2900 (rough estimate) |
| Melting Point | 124°C |
| Boling Point | 240.4±23.0 °C(Predicted) |
| Flash Point | 99.2°C |
| Water Solubility | Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water. |
| Solubility | Soluble in water (2 mg/mL at 20 °C), ethanol (1:50), chloroform (1:3), acetone (1:17) |
| Vapor Presure | 0.038mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Merck | 14,1798 |
| BRN | 144339 |
| pKa | -1.70±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.5400 (estimate) |
| MDL | MFCD00027421 |
| Physical and Chemical Properties |
|
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3335 |
| WGK Germany | 3 |
| RTECS | NJ2441000 |
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Standard
Authoritative Data Verified Data
This product is ethyl 3-methyl-2-thioimidazoline-1-carboxylate. 4 The content of C7H10N202S shall not be less than 98.5% calculated as dry.
Last Update：2024-01-02 23:10:35
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; There is extra odor.
- This product is soluble in chloroform, slightly soluble in ethanol, slightly soluble in water or ether.
melting point
The melting point of this product (General 0612) is 122~125°C.
Last Update：2022-01-01 11:36:56
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Differential diagnosis
Authoritative Data Verified Data
- Take 10mg of this product, add 5ml of water, heat to dissolve, let it cool, and add 1 ml of dilute bismuth potassium iodide solution to generate scarlet precipitate.
- take the solution containing director's determination, according to UV-visible spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 227nm and 292nm 6
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 95).
Last Update：2022-01-01 11:36:56
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Exam
Authoritative Data Verified Data
methimazole
take this product, add chloroform to dissolve and dilute to make a solution containing about 10 mg per 1 ml, as a test solution. Another methimazole control was taken, dissolved and diluted with three gases of methane to prepare a solution containing about 50ug per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel G thin layer plate, with chloroform-acetone (4:1) for the development of the agent, expand, dry, spray with dilute bismuth potassium iodide solution to color. If the test solution shows impurity spots corresponding to the control solution, the color of the test solution should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry to constant weight at 80°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 11:36:57
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Content determination
Authoritative Data Verified Data
take about 50mg of this product, precision weighing, put it in a 500ml measuring flask, add water to dissolve and dilute to the scale, shake well, take 10ml of precision children, put it in a 100ml measuring flask, add 10ml of hydrochloric acid solution (9-100), dilute to scale with water, shake well, measure absorbance at the wavelength of 292nm by UV-Vis spectrophotometry (General rule 0401), it is obtained by calculating the absorption coefficient of C7H10N202S as 557.
Last Update：2022-01-01 11:36:57
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Category
Authoritative Data Verified Data
antithyroid drugs.
Last Update：2022-01-01 11:36:58
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:36:58
ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate - Carbimazol tablets
Authoritative Data Verified Data
This product contains 90.0% to 110.0% of the label children with carbimazole (C7H10N202S).
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (approximately equivalent to 10mg of carbimazole), and show the same reaction according to item (1) of identification under the item of Carbimazole.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of NM and Nm.
examination
- Take 20 tablets of methimazole, grind it finely, add appropriate amount of chloroform, grind it to dissolve Carbimazole, filter it, wash the filter with three gas methane, combine the filtrate and washing solution, put it in a 10ml measuring flask, dilute with chloroform to the scale, shake, as a test solution; Another methimazole control, plus chloroform to make 100ug per 1 ml of the solution, as a control solution. The assay was performed according to the method under the item of Carbimazole. If the test solution shows impurity spots corresponding to the control solution, the color of the test solution should not be deeper (1.0%) than the main spot of the control solution.
- Content uniformity: Take 1 tablet of this product, put it in mortar for fine grinding, add appropriate amount of water, grind it, and transfer it to 100ml measuring flask with 80ml water in portions, continuously shake in a water bath at about 35°C for 5 minutes to dissolve the carbimazole, let it cool to room temperature, add water to the scale, shake well, filter, and accurately take 20ml of continued filtrate, according to the method under the content determination item, the content shall be determined according to the law from the "100ml measuring bottle", and the provisions shall be met (General rule 0941).
- dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid (9-1000) 600ml as the dissolution medium, the rotation speed is 50 rpm, operate according to law, after 45 minutes, take the solution 5ml, filter with filter paper, take the filtrate; According to UV-visible spectrophotometry (General 0401), measure absorbance at the wavelength of 292mn, the elution amount of each tablet was calculated as the absorption coefficient of C7H10N202S was 557. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing and taking the appropriate (about equivalent to 25mg of carbimazole), put it in a 250ml measuring flask, add about 100ml of water, continuously shake in a water bath at about 35°C for 5 minutes to dissolve the carbimazole, let it cool to room temperature, dilute to the scale with water, shake well, filter, and take 10ml of continued filtrate precisely, add 10ml of hydrochloric acid solution (9-0401) into a 100ml measuring flask, dilute with water to the scale, shake well, and measure by UV-Vis spectrophotometry (general rule), the absorbance was measured at a wavelength of 292mn, and the absorbance was calculated as 557 for C7H10N202S.
category
similar to Carbimazole.
specification
5mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:36:59
Supplier List
Spot supply
Product Name: 1-Ethoxycarbonyl-3-Methyl-2-Thioxo-4-Imidazoline Visit Supplier Webpage Request for quotationCAS: 22232-54-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: 1-Ethoxycarbonyl-3-Methyl-2-Thioxo-4-Imidazoline Visit Supplier Webpage Request for quotationCAS: 22232-54-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History