iopamiro
(S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodoisophthaldiamide
CAS: 60166-93-0;62883-00-5
Molecular Formula: C17H22I3N3O8
iopamiro - Names and Identifiers
| Name | (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodoisophthaldiamide |
| Synonyms | b-15000 iopamiro Iopamidol hthalamide -2-propylamide) (2S)-IOPAMIDOL, ISOMER MIXTURE 6-triiodo-(s)-oxy-1-oxopropyl)amino)- 1,3-benzenedicarboxamide,n,n'-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydr N,N'-BIS(1,3-DIHYDROXYPROPAN-2-YL)-5-(2-HYDROXYPROPANOYLAMINO)-2,4,6-TRIIODO-BENZENE-1,3-DICARBOXAMIDE N,N'-bis(1,3-dihydroxypropan-2-yl)-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarboxamide N,N'-bis(1,3-dihydroxypropan-2-yl)-5-{[(2S)-2-hydroxypropanoyl]amino}-2,4,6-triiodobenzene-1,3-dicarboxamide (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodoisophthaldiamide N,N'-Bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-Benzenedicarboxamide (-)-(S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-(2-hydroxypropanoylamino)-2,4,6-triiodo-benzene-1,3-dicarboxamide N-(1,3-Dihydroxypropan-2-yl)-3-{[(1,3-dihydroxypropan-2-yl)amino]methyl}-5-{[(2S)-2-hydroxypropanoyl]amino}-2,4,6-triiodobenzamide N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-[[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl]-5-[[(2S)-2-hydroxypropanoyl]amino]-2,4,6-triiodo-benzamide benzamide, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-[[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo- |
| CAS | 60166-93-0 62883-00-5 |
| EINECS | 262-093-6 |
| InChI | InChI=1/C17H22I3N3O8/c1-6(28)15(29)23-14-12(19)9(16(30)21-7(2-24)3-25)11(18)10(13(14)20)17(31)22-8(4-26)5-27/h6-8,24-28H,2-5H2,1H3,(H,21,30)(H,22,31)(H,23,29)/t6-/m0/s1 |
iopamiro - Physico-chemical Properties
| Molecular Formula | C17H22I3N3O8 |
| Molar Mass | 777.09 |
| Density | 2.0203 (estimate) |
| Melting Point | >3200C (dec) |
| Boling Point | 740.14°C (rough estimate) |
| Specific Rotation(α) | D20 -2.01° (c = 10 in water) |
| Flash Point | 428.8°C |
| Water Solubility | 473.7g/L(25 ºC) |
| Solubility | Freely soluble in water, very slightly soluble in methanol, practically insoluble in ethanol (96 per cent) and in methylene chloride |
| Vapor Presure | 5.57E-26mmHg at 25°C |
| Appearance | neat |
| pKa | pKa (25°) 10.70 |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.738 |
| Physical and Chemical Properties | Appearance practical odorless, white to off-white powder identification • infrared • color change test • liquid phase coherent with WS. On heating, Violet vapour evolves The retention time of the major peak in the chromatogram of the sample solution corresponds to that observed in the chromatogram of the S.solution specific rotation (40% solution in water) - 4.6 ° ~ - 5.2 ° loss on drying Not more than 0.5% burning residue Not more than 0.1% free aromatic amine Not more than 200 ppm free iodine No red color free iodide Not more than 0.001% free Acid or base Acid not more than 5mg of HCL equivalent. Alkali not more than 3mg of NaOHequivalent Heavy metals Not more than 0.001% Related substances Not more than 0.25% |
| Use | Raw materials for non-ionic water-soluble contrast agents. |
| In vitro study | Iopamidol significantly reduces the frequency of atrial contractions, it more significantly reduces the development of papillary muscle strength than the salt form of iodixanol. |
| In vivo study | Iopamidol increased systolic blood pressure (SBP), mean arterial pressure (MAP), and left ventricular peak systolic pressure (LVP). It increased LVP and left ventricular end-diastolic pressure more significantly than the cationic form of iodixanol. The effect of Iopamidol on cardiovascular parameters was greater than that of iodixanol. |
iopamiro - Risk and Safety
| HS Code | 2924296000 |
| Toxicity | LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder); LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre). |
iopamiro - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.287 ml | 6.434 ml | 12.869 ml |
| 5 mM | 0.257 ml | 1.287 ml | 2.574 ml |
| 10 mM | 0.129 ml | 0.643 ml | 1.287 ml |
| 5 mM | 0.026 ml | 0.129 ml | 0.257 ml |
Last Update：2024-01-02 23:10:35
iopamiro - Reference Information
| contrast agent | iopamidol, also known as iodinol, iodinol, iodinated Pentol, Iodo, Iodo, the chemical structure of the drug is an amide of triiodoisophthalic acid derivative, which has low toxicity to the blood vessel wall and nerve, good local and systemic tolerance, low osmotic pressure, low viscosity, good contrast, stable injection, the body of iodine is very little, suitable for myelography and the use of high risk factors for contrast agent reaction. After intravascular injection of iopamidol, it is excreted mainly through the kidneys. T1/2 varies with renal function, generally 2~4H, mainly unchanged with urinary excretion, 7~8H excretion of 90% ~ 95%,20h almost 100%. In vivo, iopamidol is not metabolized, does not bind to plasma proteins, and does not interfere with isozymes. due to the high iodine content, this product can attenuate X-ray to achieve the purpose of contrast imaging, and is suitable for X-ray imaging of intravascular injection. iopamidol is clinically used for various types of angiography, such as cerebral arteriography. Angiocardiography includes coronary artery, thoracic and abdominal artery, peripheral artery, vein, digital subtraction angiography. And urinary tract, joints, fistula, spinal cord, cerebral cistern and ventricles, selective visceral arteriography. Enhanced CT scan. |
| iopamidol for various imaging routes of adult usage scale | The examination project selected IP iodine concentration (mg/mL) dose (mL) spinal nerve root angiography cerebral cisternography and ventriculography CT cisternography cerebral arteriography thoracoabdominal arteriography coronary angiography Cardiovascular angiography peripheral arteriography 200~300300~300200300 370370370300~3705~155~1575~10 (high-dose shock method) 1~1.2/kg 8~15 (high dose shock) 1~1.2/kg40~50 iopamidol digital subtraction angiography (arterial) 150-300 digital subtraction angiography as needed (venous) 300~370 intravenous urography as needed CT contrast-enhanced scan selective splanchnic arteriography arthrography fistula angiography 300300~370300~370300~37030030030~5030~2/kg as needed as needed REQUIRED |
| note | 1. Severe arteriosclerosis, hypertensive heart failure, systemic disease and recent cerebral thrombosis or embolism have increased the probability of complications. Visible chest tightness, bradycardia with decreased blood pressure, Nausea, Vomit, dehydration, collapse, tinnitus, rash sweating, puncture site pain. Individual severe neurological complications. Very few have anaphylactic shock. 2. Contraindication: intrathecal injection is prohibited for patients with history of epilepsy, Waldenstrom macroglobulinemia, multiple myeloma, severe liver and kidney disease, local or systemic infection with possible bacteria. 3. Caution: excessive activity or strain, bed can not keep head upright, intracranial hypertension or intracranial tumors, blood abscess patients, patients with a history of convulsions, chronic alcoholism patients, patients with multiple sclerosis intrathecal injection with caution. To iodine allergy, allergies, hyperthyroidism, spontaneous functional thyroid nodules, high-risk patients, the elderly and children, mild to moderate liver, renal insufficiency, cardiovascular disease, diabetes, history of asthma, patients with bloody cerebrospinal fluid. As well as patients with homozygous sickle cell disease, patients with or suspected of having a cadmium-bearing cell tumor, heteroglobulinemia, hypercysteinuria, general anesthesia, congestive heart failure caused by hyperosmolar, chronic emphysema patients undergoing angiocardiography. 4. Compatibility with other drugs is prohibited. If concomitant use with thioridazine increases the risk of cardiotoxicity, concomitant use of iopamidol with metformin may result in Lactic acidosis and can lead to acute renal failure. 5. Adverse Reactions: The side effects of iopamidol are directly related to the concentration, dose and mode of administration. The osmotic pressure, viscosity and administration speed can affect the incidence and severity of side effects. Common Head Pain, Head Pain of patients with dehydration intrathecal administration of frequent episodes of exacerbation. Rare episodes of mild toxicity. Can cause dehydration, especially in elderly patients, ammonia or weakened patients may appear Shock. In addition, vertigo, Nausea, Vomit, and mental symptoms were observed. |
| biological activity | Iopamidol (Iopamiro, Isovue, Iopamiron, Niopam, Solutrast) is a non-ionic, A water-soluble contrast agent. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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