isopropyl triflate
ISOPROPYL TRIFLUOROMETHANESULFONATE
CAS: 41029-44-1
Molecular Formula: C4H7F3O3S
isopropyl triflate - Names and Identifiers
isopropyl triflate - Physico-chemical Properties
| Molecular Formula | C4H7F3O3S |
| Molar Mass | 192.16 |
| Density | 1.385±0.06 g/cm3(Predicted) |
| Boling Point | 133.5±35.0 °C(Predicted) |
isopropyl triflate - References
| Use | isopropyl trifluoromethanesulfonate belongs to trifluoromethanesulfonate esters, which is a very useful class of reagents in organic synthesis and is often used as an alkylating agent. Due to the strong electron-withdrawing ability of the trifluoromethanesulfonyl group, the reactivity is much higher than that of conventional alkylating agents, such as chlorides or alkyl sulfonates. |
| preparation | method 1. Triisopropyl orthoformate (5.71g,30mmol) slowly added to trifluoromethanesulfonic acid anhydride (5.0ml, 30mmol), 15 min NMR monitoring, the reaction was completed, reduced pressure distillation to obtain trifluoromethanesulfonic acid isopropyl Ester colorless liquid 4.32g, yield 75%. TfO(i-Pr): B. p.25 °c (1mmHg);1H NMR (5.19 MHz,CDCl3)δ5.25-1.52 (m,1H), 6.3 (d, J = Hz,7h);13C NMR(101MHz,CDCl3) Δ118.5 (q,J = 320.5Hz),86.4,23.0;19F NMR (376MHz,CDCl3) Δ-75.9 (s,3F). (1) trifluoromethanesulfonyl chloride 16.8g(0.1mol) was dissolved in 40ml of pyridine solvent, and isopropanol 6.0g(0.1mol) was slowly added dropwise at room temperature, the mixture was stirred for 3 hours;(2) the solvent was recovered under reduced pressure, and the resulting residue was dissolved in 30ml of ethyl acetate to obtain an ester layer. The Ester layer was washed with water, and the ester layer was dried over anhydrous sodium sulfate, the ethyl acetate was removed under reduced pressure to obtain 18.4g of crude isopropyl triflate in a yield of 95.8. |
Last Update：2024-04-09 20:52:54
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Product Name: Isopropyl Triflate Visit Supplier Webpage Request for quotationCAS: 41029-44-1
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Mobile: 86+15671228036
QQ: 2853786052
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