mPEG3-propionic acid - Names and Identifiers
mPEG3-propionic acid - Physico-chemical Properties
| Molecular Formula | C10H20O6
|
| Molar Mass | 236.26 |
| Density | 1.105±0.06 g/cm3(Predicted) |
| Boling Point | 352.3±32.0 °C(Predicted) |
| Appearance | Colorless liquid |
| pKa | 4.28±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
mPEG3-propionic acid - Reference Information
| biological activity | m-PEG3-CH2CH2COOH is a non-cleavable ADC linker for the synthesis of antibody-coupled drugs (ADC). m-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
| target | Non-cleavable PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 19:05:03
