menadione sodium bisulfite
menadione sodium bisulfite
CAS: 130-37-0
Molecular Formula: C11H11NaO5S
menadione sodium bisulfite - Names and Identifiers
| Name | menadione sodium bisulfite |
| Synonyms | MENADIONE SODIUM BISULFITE menadione sodium bisulfite VITAMIN K3 SODIUM BISULFITE Menadione sodium hydrogen sulfite 2-METHYL-1,4-NAPHTHOQUINONE SODIUM BISULFITE 2-METHYL-1,4-NAPHTHOQUINONE SODIUM BISULFATE 2-Methyl-1,4-naphthoquinone sodium bisulfite trihydrate 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonicacisodiumsalt 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonicacidsodiumsalt |
| CAS | 130-37-0 |
| EINECS | 204-987-0 |
| InChI | InChI=1/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1 |
menadione sodium bisulfite - Physico-chemical Properties
| Molecular Formula | C11H11NaO5S |
| Molar Mass | 278.25 |
| Melting Point | 121-124°C |
| Solubility | No odor, soluble in water, insoluble in ethanol, almost insoluble in ether and benzene, stable at room temperature, easy to decompose in light, irritating to skin and respiratory tract. |
| Appearance | White to white-like powder |
| Storage Condition | -20°C |
| MDL | MFCD00051456 |
menadione sodium bisulfite - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
menadione sodium bisulfite - Nature
Open Data Verified Data
white to light yellow crystalline powder, no or slightly odorous. Hygroscopic, decomposed in light. Soluble in water, ethanol-soluble, insoluble in ether or benzene.
Last Update：2024-01-02 23:10:35
menadione sodium bisulfite - Preparation Method
Open Data Verified Data
with O-methyl naphthoquinone as raw material, prepared by oxidation and addition.
Last Update：2022-01-01 10:10:45
menadione sodium bisulfite - Standard
Authoritative Data Verified Data
This product is a mixture of menadione sodium bisulfite and sodium bisulfite. Calculated as dry, the content of C11H9NaO5S • 3H20 should be 63.0% ~ 75.0%; The content of NaHS03 should be 30.0% ~ 38.0%.
Last Update：2024-01-02 23:10:35
menadione sodium bisulfite - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder; No odor or micro special odor; There is a hygroscopicity; Easy to decompose in light.
- This product is soluble in water, almost insoluble in ethanol or ether.
Last Update：2022-01-01 11:44:08
menadione sodium bisulfite - Use
Open Data Verified Data
can promote the synthesis of prothrombin in the liver of livestock and poultry, and promote the synthesis of plasma coagulation factors in the liver.
Last Update：2022-01-01 10:10:45
menadione sodium bisulfite - Differential diagnosis
Authoritative Data Verified Data
- take about 50mg of this product, add 5ml of water to dissolve, add 0.1 mol / L sodium hydroxide solution Dropwise, I .e. fresh yellow precipitate.
- take about 80mg of this product, add 2ml of water to dissolve, add a few drops of dilute hydrochloric acid, warm, that is, the odor of sulfur dioxide.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 457).
Last Update：2022-01-01 11:44:09
menadione sodium bisulfite - Exam
Authoritative Data Verified Data
sodium bisulfite menadione
take this product O.lg, add 5ml of water to dissolve, add 2 drops of O-Phenanthroline test solution, and do not precipitate.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 9.0% ~ 13.0%.
Last Update：2022-01-01 11:44:09
menadione sodium bisulfite - Content determination
Authoritative Data Verified Data
sodium bisulfite
take about 1.5g of this product, weigh it accurately, put it in a 100ml measuring flask, add water, shake it to dissolve and dilute it to the scale, shake it well, take 15ml for precision measurement, put it in a plug Erlenmeyer flask, add 25ml of Iodine titration solution (0.05mol/L), pack and mix it, place it for 5 minutes, slowly add 1 ml of hydrochloric acid, and use sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add 3ml of starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of Iodine titration solution (0.05 mol/ L) is equivalent to 5.203mg of NaHS03.
sodium argon sulfite menaphthalic acid
operation in the dark. Take this product about l. Add 200ml measuring flask, add water to dissolve and dilute to the scale, shake well, take 20ml accurately, put it in separatory funnel, add 40ml trichloromethane and 5ml sodium carbonate solution, shake vigorously for 30 seconds, stand still, separate the chloroform layer, filter the absorbent cotton moistened with chloroform, put the filtrate into a 200ml measuring flask, immediately wash the filter with three methane 40ml, and incorporate the washing solution into the measuring flask, the water layer was extracted with three gas methane shaking for 2 times, each time 20ml, the extract was filtered, and the filter was washed with three gas methane 20ml, the extract and the washing solution were placed in the measuring flask, diluted with chloroform to the scale, and shaken, take 2ml, put it in a 0401 measuring flask, dilute it to scale with absolute ethanol, shake well, and measure it by UV-Vis spectrophotometry (general rule), the absorbance was measured at a wavelength of 250nm with 2% chloroform in absolute ethanol solution as a blank. Another 50mg menadione reference substance was measured and placed in a 250ml measuring flask, add three gas methane to dissolve and dilute to the scale, shake well, take 2ml accurately, put it in a 100ml measuring flask, dilute to the scale with absolute ethanol, shake well, measure and calculate with the same method, and the result is multiplied by 1.918, that is The test product contained the amount of C11H9Na05S.3 H20.
Last Update：2022-01-01 11:44:10
menadione sodium bisulfite - Category
Authoritative Data Verified Data
vitamins.
Last Update：2022-01-01 11:44:10
menadione sodium bisulfite - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:44:11
menadione sodium bisulfite - Menadione Sodium Bisulfite Injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of menadione sodium bisulfite. Menadione containing sodium bisulfite (C11H9NaO5S • 3H20) shall be between 90.0% and 110.0% of the labeled amount.
trait
This product is colorless clear liquid, easy to decompose in light.
identification
take an appropriate amount of this product and show the same reaction according to the test of identification (1) and (2) under the item of menadione sodium bisulfite.
examination
- pH value should be 2.0~4.0 (General 0631) ^
- bacterial endotoxin take this product, according to the law inspection (General 1143), per 1 mg of sodium bisulfite menadione containing endotoxin should be less than 20EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
operation in the dark. Take an appropriate amount of this product (about 20mg equivalent to menadione), put it in a separatory funnel, add 40ml of trimethyl methane and 2.5ml of sodium carbonate solution, shake it vigorously for 30 seconds, stand still, and separate the chloroform layer, filter the absorbent cotton moistened with chloroform, put the filtrate into a 100ml measuring flask, immediately wash the filter with chloroform 20ml, wash the flask with washing solution, and extract the water layer twice with chloroform shaking, 10ml each time, the extract was filtered, and the filter was washed with chloroform 20ml. The extract was combined with the wash solution in a measuring flask, diluted with chloroform to the scale, and shaken. Precisely measure 2ml, put it in a 100ml measuring flask, dilute it to the scale with absolute ethanol, shake it well, and measure it by UV-Vis spectrophotometry (General rule 0401), the absorbance was measured at the wavelength of 250nm with 2% chloroform in anhydrous fermentation solution as blank; Another 20mg of linaphene reference substance was added, and then the sample was placed in a 100ml measuring flask, add three gas methane to dissolve and dilute to the scale, shake well, take 2ml accurately, put it in a 100ml measuring flask, dilute to the scale with absolute ethanol, shake well, measure and calculate with the same method, the results are multiplied by 1.918 to obtain the amount of C11H9Na05S • 3H20 contained in the test product.
category
menadione with sodium bisulfite.
specification
(l ) lml:2mg (2 )lml:4mg
storage
light shielding, closed storage.
Last Update：2022-01-01 11:44:11
menadione sodium bisulfite - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | menadione sodium bisulfite is a drug suitable for vitamin k deficiency, hypothrombinemia and neonatal natural hemorrhage. It is suitable for hemorrhagic diseases caused by vitamin K deficiency, such as neonatal hemorrhage, vitamin K deficiency caused by intestinal malabsorption, and hypothrombinemia. |
| properties | naphthoquinone sodium bisulfite is white crystalline powder; Odorless or slightly smelly; It is hygroscopic and easy to decompose when exposed to light. This product is soluble in water and almost insoluble in ethanol, ether or benzene. |
| physiological function and function | naphthoquinone sodium bisulfite is an indispensable vitamin in animal life activities. it participates in the synthesis of thrombin in animal liver and has unique hemostatic effect. at the same time, it can also prevent livestock and poultry from weak physique and subcutaneous hemorrhage. The application of this product before and after the beak of wrinkled chicken can reduce bleeding, accelerate wound healing and accelerate growth. This product can be used with sulfonamides to reduce or avoid its toxic reactions; it can be used with anti-coccidian, pullorum and avian cholera drugs to enhance its preventive effect. When there are stress factors, the application of this product can relieve or eliminate the stress state and improve the feeding effect. |
| pharmacokinetics | after intramuscular absorption, with the transport of β lipoprotein, the effect starts to be obvious in about 8-24 hours, and it takes several days to restore prothrombin to normal level. It is excreted by kidney and biliary tract in the form of glucuronic acid and sulfuric acid conjugate. |
| pharmacological action | sodium bisulfite menadione is a synthetic vitamin K(K3). Vitamin K is a substance necessary for liver synthesis factors II, VII, IX, and X. After vitamin K reaches the cell, it can be converted into epoxyphylloquinone under the action of microsomal cyclooxygenase. Epoxyphylloquinone contributes to the precursor of factor II (non-functional precursor protein) amino-terminal γ-carboxyl glutamate Carboxyl effect. Vitamin K deficiency can cause disorders or abnormalities in the synthesis of these coagulation factors. Clinical bleeding tendency and prothrombin time are prolonged. |
| indications | sodium bisulfite menadione can be used for hemorrhagic diseases caused by vitamin k deficiency, such as neonatal hemorrhage, vitamin k deficiency caused by intestinal malabsorption and hypothrombinemia. |
| application | menadione sodium bisulfite is used for patients with obstructive jaundice, biliary fistula, chronic diarrhea and absorption dysfunction caused by extensive intestinal resection. Participate in the synthesis of thrombin in animal liver, promote the formation of prothrombin, accelerate coagulation, and maintain normal coagulation time. |
| adverse reactions | sodium bisulfite menadione (Menadione Sodium Bisulfite), vitamin K deficiency, hypothrombinemia and natural neonatal hemorrhage. Such as neonatal hemorrhage, vitamin K deficiency caused by intestinal malabsorption and hypothrombinemia. |
| store | menadione sodium bisulfite should be shaded and stored in a dry and low temperature place. |
Last Update：2024-04-09 21:00:56
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Spot supply
Product Name: Menadione sodium bisulfite Visit Supplier Webpage Request for quotationCAS: 130-37-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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