methyl 3-hydroxy-2,2-dimethylpropanoate
methyl 2,2-dimethyl-3-hydroxypropionate
CAS: 14002-80-3
Molecular Formula: C6H12O3
methyl 3-hydroxy-2,2-dimethylpropanoate - Names and Identifiers
methyl 3-hydroxy-2,2-dimethylpropanoate - Physico-chemical Properties
| Molecular Formula | C6H12O3 |
| Molar Mass | 132.16 |
| Density | 1.036g/mLat 25°C(lit.) |
| Melting Point | -16 °C |
| Boling Point | 177-178°C740mm Hg(lit.) |
| Flash Point | 169°F |
| Water Solubility | Soluble in water |
| Vapor Presure | 0.105mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless |
| pKa | 14.21±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.428(lit.) |
methyl 3-hydroxy-2,2-dimethylpropanoate - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29181990 |
methyl 3-hydroxy-2,2-dimethylpropanoate - Reference Information
| Use | methyl hydroxytrimethyl acetate is also known as methyl 2, 2-dimethyl-3-hydroxypropionate, methyl hydroxy-pivalate or methyl hydroxy-pivalate. Methyl hydroxytrimethyl acetate is an important raw material for the synthesis of liquid crystal materials, pharmaceutical intermediates and dyes. It is widely used in the fields of saturated polyester resin, polyurethane, plasticizer and so on, high-grade raw material of paint and coating; It is also an important intermediate for the synthesis of herbicide isoxabalone. |
| preparation | First step: aldol condensation reaction: In a 500mL vessel, fill 36.05G of isobutyraldehyde, 41.29G formaldehyde solution with mass concentration of 40%, 0.7g catalyst, stirred at 60 ℃ for 3H; After the reaction is finished, the catalyst is removed by hot filtration, and the organic layer is separated by standing at room temperature; Step 2: oxidation and esterification reaction: the organic layer obtained in the above first step is put into a 500mL container, 40% of methanol is added, and 30ml of sodium hydroxide solution with a mass concentration of is added at 35 ° C, oxygen was introduced to a gas pressure of 0.5Mpa, and the reaction was stirred for 1H to remove formaldehyde and water to obtain methyl hydroxytrimethyl acetate. |
Last Update：2024-04-09 15:16:45
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