methyl 5-methyl-1H-indole-2-carboxylate

methyl 5-methyl-1H-indole-2-carboxylate - Names and Identifiers

Name	1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester
Synonyms	methyl 5-methyl-1H-indole-2-carboxylate 5-methyl-1H-Indole-2-carboxylic acid methyl ester 1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester
CAS	102870-03-1

methyl 5-methyl-1H-indole-2-carboxylate - Physico-chemical Properties

Molecular Formula	C11H11NO2
Molar Mass	189.21054
Density	1.212±0.06 g/cm3(Predicted)
Boling Point	345.1±22.0 °C(Predicted)
pKa	15.14±0.30(Predicted)
Storage Condition	2-8°C

methyl 5-methyl-1H-indole-2-carboxylate - Introduction

1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester is an organic compound with the chemical formula C10H9NO2. It has a pyrrole ring and a carboxyl group. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

Nature:
1. Appearance: 1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester is a solid, common form is white crystalline powder.
2. Solubility: It can be dissolved in organic solvents (such as ethanol, acetone and dimethylformamide), but the solubility in water is poor.
3. Melting Point: its melting point is 89-91 ℃.
4. Stability: It is relatively stable at regular temperatures and pressures.

Use:
1. Intermediate: 1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester is an important intermediate for the synthesis of other compounds. It can be used in the preparation of plant hormones, anti-tumor drugs, antibiotics and other drugs.
2. Chemical research: It is widely used in organic synthesis to construct the skeleton of various organic compounds.

Method:
1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester can be prepared by a variety of methods. A common method is the reaction of 5-methyl-lH-indole-2-carboxylic acid with methanol, catalyzed by common esterifying agents such as sulfuric acid, phosphorus trichloride, sulfurous chloride or acidic resins.

Safety Information:
1. 1H-Indole-2-carboxylic acid, 5-Methyl-, Methyl ester should be operated in a well-ventilated place to avoid inhalation or skin contact.
2. Wear appropriate personal protective equipment (such as gloves, glasses, etc.) when using.
3. Avoid contact with strong oxidants to avoid dangerous reactions.
4. Storage, should be kept in a dry, dark, low temperature environment, and away from flammables and oxidants.
5. When handling or disposing of residues, comply with relevant regulations and safe operation regulations.

Last Update：2024-04-09 02:00:51