Molecular Formula | C16H22O4 |
Molar Mass | 278.34 |
Density | 1.051±0.06 g/cm3(Predicted) |
Boling Point | 315.7±10.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
Appearance | Oil |
Color | Colourless |
Storage Condition | Sealed in dry,Room Temperature |
In vitro study | Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC 50 value of 38 μM. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
10 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
biological activity | Butyl isobutyl phthate (BIP) is a kind of rhizome isolated from Laminaria japonica, A non-competitive inhibitor of α-glucosidase with an IC50 value of 38 μm. Butyl isobutyl phtalate has a significant hypoglycemic effect and potential for the treatment of diabetes. |
Target | Value |
α-glucosidase (Cell-free assay) | 38 μM |
Animal Model: | Streptozocin induced diabetic mice (Male Kunming mice) |
Dosage: | 25, 50 or 100 mg/kg |
Administration: | Intragastric administration |
Result: | Had the observed antidiabetes activity in mice. |