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o-Anisidine, 5-methyl-

4-methyl-2-aminoanisole

CAS: 120-71-8

Molecular Formula: C8H11NO

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o-Anisidine, 5-methyl- - Names and Identifiers

Name 4-methyl-2-aminoanisole
Synonyms Cresidine
krezidine
azoic red
NCI-C02982
p-Cresidine
Para-Cresidine
C.I. Azoic Red 83
5-Methyl-o-Anisidine
o-Anisidine, 5-methyl-
4-methyl-2-aminoanisole
2-Methoxy-5-methylaniline
4-methoxy-3-methylaniline
o-anisidine,5-methyl-(8ci)
2-Amino-p-cresolmethylether
m-amino-p-cresol,methylester
2-Amino-p-cresol methyl ether
2-Amino-4-methylphenolmethylether
meta-amino-para-cresol,methylether
CAS 120-71-8
EINECS 204-419-1
InChI InChI=1/C8H11NO/c1-6-5-7(9)3-4-8(6)10-2/h3-5H,9H2,1-2H3
InChIKey WXWCDTXEKCVRRO-UHFFFAOYSA-N

o-Anisidine, 5-methyl- - Physico-chemical Properties

Molecular FormulaC8H11NO
Molar Mass137.18
Density1.0252 (rough estimate)
Melting Point50-52 °C (lit.)
Boling Point235 °C (lit.)
Flash Point>230°F
Water SolubilitySlightly soluble in hot water.
Solubility Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly)
Vapor Presure2.6Pa at 20℃
Vapor Density4.7 (vs air)
AppearanceCrystalline Chunks
ColorBrown to black
BRN637071
pKa4.66±0.10(Predicted)
Storage ConditionRoom Temperature, under inert atmosphere
StabilityAir Sensitive
Refractive Index1.5647 (estimate)
Physical and Chemical Properties

trait light red crystals.

soluble in ethanol, ether and hydrochloric acid. <0.1g/100 mL at 22 C

in water

Melting Point: 53 °c

Boiling Point: 235 ℃

flash point: 110 ℃

UseSuitable for the synthesis of direct, disperse and reactive dyes

o-Anisidine, 5-methyl- - Risk and Safety

Risk CodesR45 - May cause cancer
R22 - Harmful if swallowed
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany3
RTECSBZ6720000
FLUKA BRAND F CODES9
HS Code29222990
Hazard ClassIRRITANT

o-Anisidine, 5-methyl- - Upstream Downstream Industry

Raw MaterialsSodium sulfide
Dimethyl sulfate
Sodium hydroxide
Downstream Products4-amino-5-methoxytoluene-2-sulphonic acid
Direct Grey D

o-Anisidine, 5-methyl- - Nature

Open Data Verified Data

white crystals. Melting point 51.5 °c, boiling point 235 °c. Insoluble in water, soluble in alcohol, ether, insoluble in benzene.

Last Update：2024-01-02 23:10:35

o-Anisidine, 5-methyl- - Preparation Method

Open Data Verified Data
  1. p-chlorotoluene was prepared by nitration, methoxylation and reduction reaction.
  2. p-chloro-N,N-ethylbenzylamine was prepared by nitration, methoxylation and reduction.
Last Update：2022-01-01 10:51:56

o-Anisidine, 5-methyl- - Use

Open Data Verified Data

This product is a dye intermediate. It is used in the synthesis of C.I. I.29050, 29065, 27885, etc. In the case of acid dyes for the synthesis of c. I .14940, 14965, etc.

Last Update：2022-01-01 10:51:56

o-Anisidine, 5-methyl- - Safety

Open Data Verified Data
  • This product is toxic and irritating. Toxic gases are emitted from heat. Rinse with water for skin contact and wash thoroughly with soap.
  • The packing shall be lined with bedding material in the outer wooden case of the glass bottle. Store in a cool, ventilated warehouse, away from fire, heat source, avoid direct sunlight, and edible raw materials Isolation storage and transportation.
Last Update：2022-01-01 10:51:57

o-Anisidine, 5-methyl- - Reference Information

LogP1.65 at 23℃ and pH7
NIST chemical information information provided by: webbook.nist.gov (external link)
(IARC) carcinogen classification 2B (Vol. 27, Sup 7) 1987
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Application suitable for synthesis of direct, disperse and reactive dyes
This product is a dye intermediate. In terms of direct dyes for the synthesis of C. 29050, 29065, 27885, etc., in terms of acid dyes for the synthesis of C. 14940, 14965, etc., are also used in the manufacture of dispersed red GC, direct Fast Blue 3RLL, direct black D, active yellow brown K-GR, cationic Yellow 4G, etc.
3-amino-p-methylanisole is a dye intermediate. In terms of direct dyes for the synthesis of C.I.29050;29065;27885, et al., in terms of acid dyes for the synthesis C.I.14940;14965, et al., also used in the manufacture of disperse scarlet GC; Direct sunfast blue 3RLL; Direct black D; Active yellow brown K-GR; Cationic Yellow 4G, etc.
This product is a kind of dye intermediate. In terms of direct dyes for the synthesis of C.I.29050;29065;27885, et al., in terms of acid dyes for the synthesis C.I.14940;14965, et al., also used in the manufacture of disperse scarlet GC; Direct sunfast blue 3RLL; Direct black D; Active yellow brown K-GR; Cationic Yellow 4G, etc.
production method 1. It is obtained by nitration, methoxylation and reduction of P-chlorotoluene. The mixed acid was added to p-chlorotoluene at 15-20 ℃, stirred at 30 ℃ for 2H, diluted with water, and the waste acid was separated and washed with water to obtain 4-chloro-3-nitrotoluene (yield: 30.6%). And 4-chloro-2-nitrotoluene (yield 56.7%), which were separated by fractional distillation and crystallization to give 4-chloro-3-nitrotoluene. It was reacted with methanol and sodium methoxide solution, and neutralized with sulfuric acid to give 3-nitro-4-methoxytoluene in 85.6% yield. After reduction with water, iron powder and formic acid, the solvent gasoline is extracted and distilled several times. 2. 2-nitro-4-cresol was obtained by nitration of p-cresol, then methylated with dimethyl sulfate to 3-nitro-4-p-methoxytoluene, and finally reduced with sulfide base. P-chloro-N,N-diethylbenzylamine was prepared by nitration, methoxylation and reduction.
category toxic substances
toxicity grade poisoning
Acute toxicity oral-rat LD50: 1450 mg/kg
stimulation data Skin-rabbits 500 mg/24 h mild; eye-rabbit 100 mg/24 h moderate
flammability hazard characteristics open flame flammable; Toxic aniline gas emitted by heat
storage and transportation characteristics The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials
fire extinguishing agent water, carbon dioxide, sand, dry powder
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 15:16:45
o-Anisidine, 5-methyl-
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Jiangsu Pules Biotechnology Co.,Ltd.
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CAS: 120-71-8
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 4-methyl-2-aminoanisole Request for quotation
CAS: 120-71-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 4-methyl-2-aminoanisole Request for quotation
CAS: 120-71-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: 2-Methoxy-5-methylan Request for quotation
CAS: 120-71-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
View History
o-Anisidine, 5-methyl-
Raw Materials for o-Anisidine, 5-methyl-
Sodium sulfide
Dimethyl sulfate
Sodium hydroxide
Downstream Products for o-Anisidine, 5-methyl-
4-amino-5-methoxytoluene-2-sulphonic acid
Direct Grey D
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