p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste
Camostat mesilate
CAS: 59721-29-8
Molecular Formula: C21H26N4O8S
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste - Names and Identifiers
| Name | Camostat mesilate |
| Synonyms | Camostatemesylate CAMOSTAT MESYLATE Camostat mesilate CAMOSTAT MESILATE ino)-2-oxoethylester,monomethanesulfonate p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-benzeneaceticaci2-(dimethylam n,n-dimethylcarbamoylmethyl4-(4-guanidinobenzoyloxy)phenylacetatemethanesul 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate N-(diaminomethylidene)-4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilinium methanesulfonate |
| CAS | 59721-29-8 |
| EINECS | 694-565-6 |
| InChI | InChI=1/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4) |
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste - Physico-chemical Properties
| Molecular Formula | C21H26N4O8S |
| Molar Mass | 494.52 |
| Melting Point | 150-1550C |
| Boling Point | 634.6°C at 760 mmHg |
| Flash Point | 337.6°C |
| Water Solubility | Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml). |
| Solubility | H2O: ≥24mg/mL |
| Vapor Presure | 5.22E-16mmHg at 25°C |
| Appearance | powder |
| Color | white to tan |
| Merck | 14,1728 |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years? from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| In vitro study | Camostat (30 μm) prolongs the attenuation of ENaC function in a human airway epithelial cell model and is reversible with the addition of excess trypsin. Camostat mesilate (500 mM) inhibits the production of TGF-beta by inhibiting Plasmin Activity and reduces the activity of TGF-beta, which blocks the activation of HSCs in vitro. Camostat mesilate (20 mM) has a significant hypoglycemic effect when administered in combination with insulin. In rat small and large intestine homogenates, Camostat mesilate (20 mM) was able to effectively reduce insulin degradation. Camostat mesilate (2 mM) inhibits MCP-1 and TNF-production in activated monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production in cultured rat PSCs. |
| In vivo study | Camostat (100 μg/kg I. T.) was effective in prolonging the attenuation of ENaC activity in the Guinea Pig trachea. In porcine serum-treated rats, Camostat mesilate (1-2 mg/g diet) significantly attenuated the increase in hepatic plasmin and TGF-beta levels, HSC activation, and hepatic fibrosis, there were no significant systemic or local side effects. Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function in DBTC-induced rats with chronic pancreatitis. Camostat mesilate (1 mg/g) inhibits chronic inflammation, and DBTC-induced pancreatic fibrosis. Camostat mesilate (1 mg/g) inhibits the development of DBTC-induced pancreatic fibrosis and PSCs activation in the pancreas. In serum and pancreatic tissue, Camostat mesilate (1 mg/g) inhibited mononuclear cell infiltration and inhibited MCP-1 expression. In rats with chronic pancreatitis, Camostat mesilate (100 mg/kg) significantly increased body weight and pancreatic wet weight, and by inhibiting PAP,p8, and cytokine gene expression, significantly inhibits inflammatory changes and fibrosis of the pancreas. |
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | CY1571620 |
| Hazard Class | 9 |
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.022 ml | 10.111 ml | 20.222 ml |
| 5 mM | 0.404 ml | 2.022 ml | 4.044 ml |
| 10 mM | 0.202 ml | 1.011 ml | 2.022 ml |
| 5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
Last Update：2024-01-02 23:10:35
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View History
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste
hexane-1,6-diyl bis(2-methylprop-2-enoate)
4-(Octyloxy)benzenamine
hexane-1,6-diyl bis(2-methylprop-2-enoate)
4-(Octyloxy)benzenamine