p-Aminobenzoic acid methyl ester
4-aminobenzoic acid methyl ester
CAS: 619-45-4
Molecular Formula: C8H9NO2
p-Aminobenzoic acid methyl ester - Names and Identifiers
| Name | 4-aminobenzoic acid methyl ester |
| Synonyms | methyl 4-aminobenzoate p-(Methoxycarbonyl)aniline methylaniline-4-carboxylate Methyl aniline-4-carboxylate p-aminobenzoicacidmethylester 4-aminobenzoic acid methyl ester benzoicacid,4-amino-,methylester p-Aminobenzoic acid methyl ester Methyl ester of 4-aminobenzoic acid Methyl ester of p-Aminobenzoic acid |
| CAS | 619-45-4 |
| EINECS | 210-598-7 |
| InChI | InChI=1/C8H9NO2.ClH/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5H,9H2,1H3;1H |
| InChIKey | LZXXNPOYQCLXRS-UHFFFAOYSA-N |
p-Aminobenzoic acid methyl ester - Physico-chemical Properties
| Molecular Formula | C8H9NO2 |
| Molar Mass | 151.16 |
| Density | 1.2023 (rough estimate) |
| Melting Point | 110-111 °C (lit.) |
| Boling Point | 273.17°C (rough estimate) |
| Flash Point | 154.9°C |
| Water Solubility | Soluble in alcohol and ether. Slightly soluble in water. |
| Solubility | Soluble in ethanol and ether, slightly soluble in water. |
| Vapor Presure | 0.00121mmHg at 25°C |
| Appearance | White to light brown crystals |
| Color | White to beige |
| BRN | 775913 |
| pKa | pK1:2.38(＋1) (25°C) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5810 (estimate) |
| MDL | MFCD00007891 |
| Physical and Chemical Properties | Flaky crystals. Melting point of 112 ° C, soluble in ethanol and ether, water-soluble. |
| Use | Used as a dye intermediate |
p-Aminobenzoic acid methyl ester - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| RTECS | DG2900000 |
| TSCA | Yes |
| HS Code | 29224995 |
p-Aminobenzoic acid methyl ester - Introduction
Organic synthesis. Spice synthesis.
Last Update：2022-10-16 17:27:13
p-Aminobenzoic acid methyl ester - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | methyl 4-aminobenzoate, also known as methyl p-aminobenzoate, is an aromatic amine and an important organic chemical intermediate, widely used in medicine, materials, dyes, pesticides and other fields. |
| preparation | methyl 4-aminobenzoate is a carboxylic acid ester derivative and can be obtained by reducing a nitro group from methyl p-nitrobenzoate. |
| Use | for organic synthesis. used as dye intermediate |
| production method | p-nitrobenzoic acid is esterified with methanol and then reduced with iron powder. P-nitrobenzoic acid was heated with methanol and sulfuric acid, and esterified for 6-8H under reflux. After methanol was recovered, the esterification product was poured into ice water for crystallization, filtered, and washed with water, sodium hydroxide solution and water in turn to obtain methyl p-nitrobenzoate. This was added to a mixture of hydrochloric acid, iron powder and water, and heated to micro-boiling for about 0.5 hours. Cooling, filtration, extraction with benzene, benzene recovery after the crude product, and then recrystallized with methanol, that is, methyl p-aminobenzoate. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intraperitoneal-mouse LD50: 237 mg/kg |
| flammability hazard characteristics | flammability; Toxic nitrogen oxides and hydrogen chloride fumes from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-09 20:48:19
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