p21-Activated Kinase Inhibitor III, IPA-3
IPA-3
CAS: 42521-82-4
Molecular Formula: C20H14O2S2
p21-Activated Kinase Inhibitor III, IPA-3 - Names and Identifiers
| Name | IPA-3 |
| Synonyms | IPA3 IPA 3 IPA-3 1,1'-Dithiodi-2-naphthtol 2-Naphthalenol, 1,1'-dithiobis- 1,1′-Disulfanediyldinaphthalen-2-ol Bis(2-hydroxy-1-naphthyl) disulfide p21-Activated Kinase Inhibitor III, IPA-3 |
| CAS | 42521-82-4 |
p21-Activated Kinase Inhibitor III, IPA-3 - Physico-chemical Properties
| Molecular Formula | C20H14O2S2 |
| Molar Mass | 350.45 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Melting Point | 172℃ |
| Boling Point | 543.7±35.0 °C(Predicted) |
| Water Solubility | Soluble in DMSO or ethanol. Insoluble in water. |
| Solubility | DMSO: >20mg/mL |
| Appearance | Yellow solid |
| Color | off-white to yellow |
| pKa | 7.52±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Sensitive | Light Sensitive |
| MDL | MFCD00388917 |
| Use | IPA-3 |
| In vitro study | IPA-3 allosteric inhibitors of p21-activated kinase 1(Pak1) that are non-ATP competitive. IPA-3 inhibition of Cdc42 stimulated Pak1 autophosphorylation at the Thr423 site. IPA-3 also inhibited sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target the cysteine residues that act on the exposed pak1. A disulfide bond of IPA-3 is critical for inhibition of Pak1 and IPA-3 inhibition of Pak1 is abolished by the reducing agent dithiothreitol (DTT). IPA-3 inhibits Pak1 activation by different activators, but does not inhibit pre-activated pak1. IPA-3 inhibits PDGF-stimulated activation of Pak in mouse embryonic fibroblasts. IPA-3 inhibition of Pak1 activation by covalent binding to the regulatory domain of pak1. IPA-3 is covalently bound to Pak1, and this effect is time and temperature dependent. IPA-3 inhibits the binding of the Pak1 activator Cdc42. IPA-3 binds directly to the autoregulatory domain of pak1. IPA-3 acting on cells, reversible inhibition of PMA induced membrane cracking. |
p21-Activated Kinase Inhibitor III, IPA-3 - Risk and Safety
| Risk Codes | R41 - Risk of serious damage to eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Hazard Class | 9 |
p21-Activated Kinase Inhibitor III, IPA-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.853 ml | 14.267 ml | 28.535 ml |
| 5 mM | 0.571 ml | 2.853 ml | 5.707 ml |
| 10 mM | 0.285 ml | 1.427 ml | 2.853 ml |
| 5 mM | 0.057 ml | 0.285 ml | 0.571 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: IPA 3 Visit Supplier Webpage Request for quotationCAS: 42521-82-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: IPA-3 Visit Supplier Webpage Request for quotation
CAS: 42521-82-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 42521-82-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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