piperidine-1-carbonyl chloride

piperidine-1-carbonyl chloride - Names and Identifiers

Name	1-piperidinecarbonyl chloride
Synonyms	NSC 50227 N-Chloroformylpiperidine 1-(Chlorocarbonyl)piperidine 1-piperidinecarbonyl chloride N-Piperidinecarbonyl chloride 1-PIPERIDINECARBONYL CHLORIDE piperidine-1-carbonyl chloride 1-Piperidinecarbonyl chloride (6CI,7CI,8CI,9CI)
CAS	13939-69-0
InChI	InChI=1/C6H10ClNO/c7-6(9)8-4-2-1-3-5-8/h1-5H2

piperidine-1-carbonyl chloride - Physico-chemical Properties

Molecular Formula	C6H10ClNO
Molar Mass	147.6
Density	1.18 g/mL at 25 °C (lit.)
Boling Point	242 °C (lit.)
Flash Point	110°C
Vapor Presure	0.0421mmHg at 25°C
pKa	-1.85±0.20(Predicted)
Storage Condition	Room Temprature
Refractive Index	n20/D 1.459(lit.)
Physical and Chemical Properties	WGK Germany:3

piperidine-1-carbonyl chloride - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3265 8/PG 3
WGK Germany	3

piperidine-1-carbonyl chloride - Introduction

1-Piperidinoyl chloride, chemical formula C6H7NCl, is an organic compound. Its nature is as follows:

1. physical properties: 1-piperidine chloride is a colorless liquid, soluble in organic solvents such as ethanol and ether, relatively insoluble in water.

2. chemical properties: 1-piperidinyl chloride is a kind of acid chloride compound, with strong electrophilicity. It can be reacted with a compound containing a reactive hydrogen atom to replace its acyl chloride group with a piperidinyl group.

Purpose: 1-Piperidinoyl chloride is widely used as an intermediate and reagent in organic synthesis. It is often used in the synthesis of other compounds, such as drugs, pesticides and dyes.

Preparation method: A common synthesis method is to react 1-piperidine with thionyl chloride to generate 1-piperidine chloride in the presence of a base. Specific reaction conditions can be adjusted according to specific experiments.

Safety Information: 1-Piperidinoyl Chloride is irritating and corrosive, and care should be taken to avoid contact with skin, eyes, and respiratory tract. Wear protective gloves, goggles and masks during use. In case of contact or accidental inhalation, rinse with plenty of water immediately and seek medical treatment in time. When stored, it should be kept in a sealed container, avoid contact with air and humidity.

Last Update：2024-04-09 02:00:42