psoralidin
Psoralidin
CAS: 18642-23-4
Molecular Formula: C20H16O5
psoralidin - Names and Identifiers
| Name | Psoralidin |
| Synonyms | psoralidin Psoralidin Psorslidin Psoralidin, BR 3,9-Dihydroxy-2-prenylcoumestan 3,9-Dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-benzofuro[3,2-c]chromen-6-one 3,9-dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c]chromen-6-one 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro(3,2-c)(1)benzopyran-6-one 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-butenyl)- 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-buten-1-yl)- |
| CAS | 18642-23-4 |
| InChI | InChI=1/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3 |
| InChIKey | YABIJLLNNFURIJ-UHFFFAOYSA-N |
psoralidin - Physico-chemical Properties
| Molecular Formula | C20H16O5 |
| Molar Mass | 336.34 |
| Density | 1.383±0.06 g/cm3(Predicted) |
| Melting Point | 290-292° |
| Boling Point | 458.8±34.0 °C(Predicted) |
| Flash Point | 231.3°C |
| Solubility | Soluble in chloroform and methanol. |
| Vapor Presure | 4.89E-09mmHg at 25°C |
| Appearance | Light yellow crystalline powder |
| Color | white to beige |
| pKa | 8.70±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.688 |
| MDL | MFCD10566617 |
| Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Psoralea corylifolia Linn. Seeds. |
psoralidin - Risk and Safety
| WGK Germany | 3 |
psoralidin - Reference
| Reference Show more | 1. Ding Yuting, Zheng Zhuhong, Zhao Renyun, et al. Rapid Analysis of Chemical Components of Psoralea corylifolia by UPLC-Q-TOF-MS ~ E Technology Combined with UNIFI Screening Platform [J]. Journal of Mass Spectrometry 2018. 2. Fan Lingqiu Xinsong Gaoyang, et al. Simultaneous Determination of 10 Components in Psoralea corylifolia by HPLC [J]. Journal of Qiqihar Medical College 2018 39(16):73-76. 3. Huang Xiaojing, zhou Xiaoying, Zhou Shiyu. Effect of Cobalt -60 Irradiation on Fingerprint of Psoralea corylifolia [J]. Chinese Drug Evaluation, 2015, 000(003):159-161. 4. Chen, Xiumin, Yanfang Yang, and Yingtao Zhang. "Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in Vitro." Febs Letters 587.18 (2013): 2930-2935.https:// doi.org/10.1016/j.febslet. 2013.07. 5. Chen, Zhi-Jing, et al. "Dietary total prenylflavonoids from the fruits of Psoralea corylifolia L. prevents age-related cognitive deficits and down-regulates Alzheimer's markers in SAMP8 mice." Molecules 23.1 (2018): 196.https://doi.org/10.3390/molecules230 6. [IF=4.072] Tiehua Zhang et al."Estrogenic properties of coumarins and meroterpene from the fruits of Cullen corylifolium: Experimental and computational studies."Phytochemistry. 2018 Aug;152:148 7. [IF=3.267] Zhi-Jing Chen et al."Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer's Markers in SAMP8 Mice."Molecules. 2018 Jan;23(1):196 8. [IF=2.675] Xiumin Chen et al."Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro."Febs Lett. 2013 Sep;587(18):2930-2935 9. [IF=1.851] Zhitao Rao et al."Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis."Mol Med Rep. 2018 Feb;17(2):3418-3424 |
psoralidin - Reference Information
| Biological activity | Psoralidin is isolated from Psoralea corylifolia seeds and is a dual inhibitor of COX-2 and 5-LOX. It has anti-cancer, antibacterial and anti-inflammatory effects. Psoralidin significantly down-regulated NOTCH1 signaling. Psoralidin also greatly induced ROS production. |
| Cell Line: | ALDH - cells, ALDH + cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A) ALDH - cells, ALDH + cells, and commercial BCSCs |
| Concentration: | 10, 15, 50, and 25 μM 20 and 30 μM |
| Incubation Time: | 24 hours 24 hours |
| Result: | IC 50 s of 18 to 21 μM for ALDH - cells, ALDH + cells, commercial BCSCs. No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH - cells, ALDH + cells, and commercial BCSCs, respectively. Anti-inflammatory effect in IR-irradiated mice. |
| Animal Model: | BALB/c mice |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy). |
| use | psoralen has antifungal, cytotoxic, coronary artery dilation and hemostasis effects. a ptp1b inhibitor with multiple anticancer mechanisms. |
Last Update：2024-04-10 22:29:15
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Product Name: Psoralidin Visit Supplier Webpage Request for quotationCAS: 18642-23-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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