pyrimidine, 5-bromo-4-chloro- - Names and Identifiers
pyrimidine, 5-bromo-4-chloro- - Physico-chemical Properties
Molecular Formula | C4H2BrClN2
|
Molar Mass | 193.43 |
Density | 1.859±0.06 g/cm3(Predicted) |
Boling Point | 250.7±20.0 °C(Predicted) |
pKa | -1.41±0.16(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
pyrimidine, 5-bromo-4-chloro- - Introduction
5-Bromo-4-chroopyrimidine is an organic compound with the chemical formula C4H2BrClN2. The following is its nature, use, preparation and safety information:
Nature:
1. Appearance: 5-Bromo-4-chroopyrimidine is a colorless to pale yellow crystal or powder.
2. Solubility: It has good solubility in common organic solvents, such as ethanol, dimethylformamide and dichloromethane.
3. Melting point: The melting point of 5-Bromo-4-chloropyrimidine is about 75-78°C.
4. Stability: It is relatively stable under the action of light and heat.
Use:
1. Chemical reagents: 5-Bromo-4-chloropyrimidine can be used as a starting compound in organic synthesis for the synthesis of biologically active molecules.
2. Drug research: It is used as an intermediate or primer in drug research for the synthesis of antiviral, antitumor and biologically active compounds.
3. Pesticide research: 5-Bromo-4-chloropyrimidine can be used in the research and synthesis of pesticides.
Preparation Method:
5-Bromo-4-chloropyrimidine can be prepared by reacting 4-chloropyrimidine with bromine under alkaline conditions. A specific procedure involves adding bromine to the reaction solvent, then slowly adding a base (such as sodium hydroxide), and finally adding 4-chloropyrimidine, and continuing the reaction for a period of time.
Safety Information:
Regarding the safety of 5-Bromo-4-chloropyrimidine, the following are some common safety precautions:
1. attention to protection: in use or handling, should wear appropriate protective gloves, glasses and masks, to ensure adequate ventilation.
2. Avoid inhalation and contact: Avoid inhaling aerosols and avoid direct skin contact with the compound.
3. Storage conditions: The compound should be stored in a cool, dry place.
4. Leakage treatment: in case of leakage, explosion-proof adsorbent should be used for cleaning.
Please note that when using any chemical, it is important to follow appropriate laboratory safety practices and follow the detailed information and safety data sheets provided by the supplier.
Last Update:2024-04-09 21:54:55