quinolin-8-yl-8-boronic acid
8-Quinoline boronic acid
CAS: 86-58-8
Molecular Formula: C9H8BNO2
quinolin-8-yl-8-boronic acid - Names and Identifiers
quinolin-8-yl-8-boronic acid - Physico-chemical Properties
| Molecular Formula | C9H8BNO2 |
| Molar Mass | 172.98 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting Point | >300°C(lit.) |
| Boling Point | 160-165°C |
| Solubility | soluble in Methanol |
| Appearance | Yellow crystalline powder |
| Color | Yellow to beige |
| Merck | 14,8069 |
| BRN | 147522 |
| pKa | 4.61±0.30(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD01114698 |
| Use | Reactant involved in: 1C-H and C- S bond activation 2Synthesis of pyridazine via sequential amination / Suzuki coupling / alkylation reactions 3 Suzuki-Miyaura coupling reactions for synthesis of biaryl monophosphorus ligands, fused tricyclic oxa- |
quinolin-8-yl-8-boronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
quinolin-8-yl-8-boronic acid - Reference Information
| Overview | quinoline -8-boronic acid is a heterocyclic organic compound that can be used as an intermediate in pharmaceutical synthesis. |
| preparation | quinoline -8-boronic acid was prepared as follows: 8-bromoquinoline (2.08g,10mmol) dissolved in 30ml of THF, n-butyl lithium (4ml, 2.5m in hexane) was added thereto at a temperature of -78 °c. After 1 H of addition, trimethyl borate (1.23ml,11mmol) was added thereto at the same temperature. The resulting solution was stirred for 5 hours, and then, 100ml of 2M HCl was added thereto, which was subjected to an extraction process three times by using 60ml of ethyl acetate. The obtained extraction portions were taken together, then dehydrated by using anhydrous magnesium sulfate, and distilled under reduced pressure. The obtained compound was isolated-purified by silica gel column chromatography to give 1.30g (yield: 75%) of quinoline-8-boronic acid in the form of a white solid. The obtained compound was confirmed by LC-MS. |
Last Update：2024-04-09 19:05:15
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