rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
TCH-165
CAS: 1446350-60-2
Molecular Formula: C39H37N3O3
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate - Names and Identifiers
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate - Physico-chemical Properties
| Molecular Formula | C39H37N3O3 |
| Molar Mass | 595.73 |
| Solubility | DMSO : 250 mg/mL (419.65 mM; Need ultrasonic) |
| Storage Condition | -20℃ |
| Use | TCH-165 are small molecule modulators of proteasome assembly that increase 20S levels and promote 20S-mediated protein degradation. |
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate - Reference
| Reference Show more | 1: Njomen E, Osmulski PA, Jones CL, Gaczynska M, Tepe JJ. Small Molecule Modulation of Proteasome Assembly. Biochemistry. 2018 Jul 17;57(28):4214-4224. doi: 10.1021/acs.biochem.8b00579. Epub 2018 Jun 27. PubMed PMID: 29897236; PubMed Central PMCID: PMC6241286. |
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.679 ml | 8.393 ml | 16.786 ml |
| 5 mM | 0.336 ml | 1.679 ml | 3.357 ml |
| 10 mM | 0.168 ml | 0.839 ml | 1.679 ml |
| 5 mM | 0.034 ml | 0.168 ml | 0.336 ml |
Last Update：2024-01-02 23:10:35
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate - Reference Information
| biological activity | TCH-165 is a small molecule regulator of proteasome assembly, increases 20S levels and promotes 20s-mediated protein degradation. |
| Target | Proteasome assembly |
| Cell Line: | RPMI8226 and U87MG cells HEK293T cells |
| Concentration: | 0.01-10 μM 0 μM, 3 μM, 10 μM |
| Incubation Time: | 72 hours 24 hours |
| Result: | Inhibited cell growth of RPMI8226 and U87MG cells with IC 50 of 1.6 μM and 2.4 μM, respectively. Enhanced proteolytic degradation in a concentration-dependent manner. |
Last Update：2024-04-09 15:16:56
