tert-Butyl 3-(2-(2-(2-hydroxyethoxy)

Name	tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Synonyms	OH-PEG3-TBA HO-PEG3-COOtBu OH-PEG3-CH2CH2COOtBu HO-PEG3-t-Butyl ester Hydroxy-PEG4-t-butyles Hydroxy-PEG3-(CH2)2-Boc 12-HYDROXY-4 7 10-TRIOXA- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- tert-Butyl 3-(2-(2-(2-hydroxyethoxy) tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
CAS	186020-66-6

Molecular Formula	C13H26O6
Molar Mass	278.34
Density	1.052 g/mL at 20 °C (lit.)
Boling Point	365.8±27.0 °C(Predicted)
BRN	7638988
pKa	14.36±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	n20/D 1.446
MDL	MFCD03791106
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

WGK Germany	3
FLUKA BRAND F CODES	10

Intermediate in the spacer arm used in synthetic combinatorial chemistry

Last Update：2022-10-16 17:41:30

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

introduction	12-hydroxy -4,7,10-tert-butyl trioxacate is an organic intermediate, which can be composed of 2,2 '-(ethane -1, 2-Dibis (oxy) diethanol and tert-butyl acrylate are prepared by one-step reaction, or by triethylene glycol monobenzyl ether and tert-butyl acrylate by two-step reaction.
preparation	adding tert-butyl acrylate (1g,7.8mmol, 1.0equiv) and benzyl trimethylammonium hydroxide (TritonB)(121mg,0.29mmol,1.0equiv,40% aqueous solution) to acetonitrile solution of diethylene glycol (5.9g,39mmol,5.0equiv), stir at room temperature for 48h,KMnO4 color to determine whether the reaction is complete, remove the solvent on a rotary evaporator, and purify the target product 12-hydroxy -4,7,10-tert-butyl trioxacate 1.6632g, oily liquid with 77% yield by silica gel column chromatography (V (petroleum ether):V (ethyl acetate) = 2:1).
biological activity	Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody-coupled drugs (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from the patented WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as PROTAC linker for PROTAC synthesis..
target	non-cleavable PEGs Alkyl/ether
in vitro study

Last Update：2024-04-10 22:29:15

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Product Name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate Visit Supplier Webpage Request for quotation
CAS: 186020-66-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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tert-Butyl 3-(2-(2-(2-hydroxyethoxy)

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