tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate - Names and Identifiers

Name	1-Boc-3-hydroxymethylpiperazine
Synonyms	PY-IM A 1-BOC-3-hydroxymethypiperazine 1-Boc-3-hydroxymethylpiperazine 4-Boc-2-hydroxymethyl-piperazine 1-Boc-3-Hydroxymethyl-piperazine 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 4-N-Boc-2-hydroxymethylpiperazine 2-(HYDROXYMETHYL)-4-N-TERT-BUTOXYCARBONYL-PIPERAZINE tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-Hydroxymethyl-Piperazine-1-Carboxylic Acid Tert-Butyl Ester 3-(HYDROXYMETHYL)-1-PIPERAZINE CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CAS	301673-16-5
InChI	InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C10H20N2O3
Molar Mass	216.28
Density	1.085±0.06 g/cm3(Predicted)
Melting Point	93.0 to 97.0 °C
Boling Point	322.9±22.0 °C(Predicted)
Flash Point	149.075°C
Vapor Presure	0mmHg at 25°C
pKa	14.97±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.478
MDL	MFCD04115304

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate - Introduction

It is an organic compound with the chemical formula C10H20N2O3. It is a solid, soluble in some organic solvents such as ether and dimethylformamide.

It is often used as an intermediate in organic synthesis reactions. It can be introduced into the molecule as a protecting group to protect nucleophilic functional groups, such as ketone or amine groups, from unwanted reactions. It can also be used as a C- hydroxymethylating reagent, playing a role in some chemical transformations, such as the synthesis of amides.

The method of preparation is usually by reacting piperazine with methyl bromide to obtain 3-methylpiperazine, and then by reacting dimethyl carbonate to introduce Boc protecting group.

For safety information, organic compounds in general require appropriate laboratory practices and handling. It may be irritating to the human body and should avoid inhalation, intake and skin contact. Wear appropriate protective goggles, gloves and laboratory clothing when operating. In case of accidental contact, rinse immediately with plenty of water and seek medical advice. During storage and handling, attention should be paid to fire and explosion prevention, and it should be placed in a sealed container for storage.

Last Update：2024-04-10 22:29:15