tert-Butyl 4-amidinopiperidine-1-carboxylate

tert-Butyl 4-amidinopiperidine-1-carboxylate - Names and Identifiers

Name	tert-Butyl 4-amidinopiperidine-1-carboxylate
Synonyms	1-Boc-4-piperidinamidine 1-Boc-4-AMidinopiperidine 1-Boc-4- carbamimidoylpiperidine tert-butyl 4-amidinopiperidine-1-carboxylate tert-Butyl 4-amidinopiperidine-1-carboxylate 4-carbamimidoyl-1-piperidinecarboxylic acid tert-butyl ester 1-Piperidinecarboxylicacid, 4-(aminoiminomethyl)-, 1,1-dimethylethyl ester 1-Piperidinecarboxylic acid, 4-(aMinoiMinoMethyl)-, 1,1-diMethylethyl ester
CAS	885270-23-5
InChI	InChI=1S/C11H21N3O2/c1-11(2,3)16-10(15)14-6-4-8(5-7-14)9(12)13/h8H,4-7H2,1-3H3,(H3,12,13)

tert-Butyl 4-amidinopiperidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C11H21N3O2
Molar Mass	227.3
Density	1.18±0.1 g/cm3(Predicted)
Boling Point	330.1±52.0 °C(Predicted)
pKa	12.00±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

tert-Butyl 4-amidinopiperidine-1-carboxylate - Introduction

tert-Butyl (tert-Butyl) is an organic compound, usually in the form of white solid crystals.

Nature:
tert-Butyl has good stability and can be stored stably at room temperature. It has low solubility and is soluble in some organic solvents such as diethyl ether, dichloromethane and alcoholic solvents. It has moderate acidity.

Use:
tert-Butyl is an important intermediate compound in the field of biology and medicine. It is mainly used in organic synthesis reactions and can be used as a medium or reagent. One of its main uses is as a protective group for the synthesis of peptide compounds, protecting the amino groups in amino acids to prevent damage during the reaction. In addition, it can also be used to synthesize biologically active compounds, such as drugs and new materials.

Preparation Method:
The preparation of tert-Butyl is usually prepared by the reaction of benzoic acid BOC imine and 4-piperidinomethylamine. In the reaction, first of all, the benzoic acid BOC imine and 4-piperidine methylamine are reacted with ammonium sulfite or sulfite as catalyst in an appropriate solvent to obtain the tert-Butyl product. Finally, the pure product was obtained by appropriate purification process.

Safety Information:
tert-Butyl is irritating and may cause discomfort when in contact with skin and eyes. Appropriate personal protective measures, such as gloves and protective glasses, are required during handling and storage. In addition, it should be ensured that the operation is carried out under well-ventilated conditions to avoid discomfort caused by inhalation. If contact or ingestion occurs, rinse immediately with plenty of water and seek medical advice.

Last Update：2024-04-09 20:52:54