tert-Butyl 5-aminoisoindoline-2-carboxylate

tert-Butyl 5-aminoisoindoline-2-carboxylate - Names and Identifiers

Name	tert-butyl 5-aminoisoindoline-2-carboxylate
Synonyms	tert-butyl 5-aMinoisoin 5-Amino-2-(tert-butoxycarbonyl)isoindoline TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE tert-butyl 5-aminoisoindoline-2-carboxylate 5-Aminoisoindoline-2-carboxylic acid tert-butyl ester tert-butyl 5-amino-1,3-dihydroisoindole-2-carboxylate tert-Butyl 5-amino-1,3-dihydro-2H-isoindole-2-carboxylate tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate 5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester 5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester 2H-isoindole-2-carboxylic acid, 5-amino-1,3-dihydro-, 1,1-dimethylethyl ester
CAS	264916-06-5
InChI	InChI=1/C13H18N2O2/c1-13(2,3)17-12(16)15-7-9-4-5-11(14)6-10(9)8-15/h4-6H,7-8,14H2,1-3H3

tert-Butyl 5-aminoisoindoline-2-carboxylate - Physico-chemical Properties

Molecular Formula	C13H18N2O2
Molar Mass	234.29
Density	1.177
Boling Point	376.3±42.0 °C(Predicted)
Flash Point	181.382°C
Vapor Presure	0mmHg at 25°C
pKa	4.76±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.582

tert-Butyl 5-aminoisoindoline-2-carboxylate - Introduction

tert-butyl is an organic compound with the chemical formula C13H18N2O2. It is in the nature of a colorless to yellowish crystalline solid with a melting point of 86-88°C and is soluble in organic solvents such as chloroform and dichloromethane.

tert-butyl is commonly used as an intermediate in organic synthesis. It can be used to synthesize isoindole derivatives, which have important biological activities in the field of medicine. It can also be used as a synthetic intermediate for dyes and pigments.

The method for preparing tert-butyl is usually through the esterification reaction of isobutanol and 5-aminoisoindole-2-carboxylic acid. First, isobutanol reacts with 5-aminoisoindole-2-carboxylic acid under acidic conditions to form an ester bond, and then the target product is purified by distillation.

When using tert-butyl, you need to pay attention to safety matters. It is an organic compound that has certain toxicity and may cause damage to the human body. Follow laboratory safety regulations, wear appropriate personal protective equipment, avoid contact with skin and eyes, and ensure good ventilation. When stored, it should be kept in a sealed container, away from fire and oxidizing agents. If necessary, consult the chemical's safety data sheets and operating manuals for detailed safety information before use.

Last Update：2024-04-09 21:01:54