tert-butyl (2-hydroxy-1-phenylethyl)carbamate

tert-butyl (2-hydroxy-1-phenylethyl)carbamate - Names and Identifiers

Name	tert-butyl (2-hydroxy-1-phenylethyl)carbamate
Synonyms	2-(Boc-aMino)-2-phenyl-ethanol tert-Butyl (2-hydroxy-1-phenylethyl) N-(tert-Butoxycarbonyl)-DL-2-phenylglycinol 2-(tert-Butoxycarbonylamino)-2-phenylethanol tert-Butyl (2-hydroxy-1-phenylethyl)carbamate tert-butyl (2-hydroxy-1-phenylethyl)carbamate Carbamic acid, N-(2-hydroxy-1-phenylethyl)-, 1,1-dimethylethyl ester N-Boc-DL-2-phenylglycinol2-(tert-Butoxycarbonylamino)-2-phenylethanol
CAS	67341-01-9
InChI	InChI=1/C13H19NO3/c1-13(2,3)17-12(16)14-11(9-15)10-7-5-4-6-8-10/h4-8,11,15H,9H2,1-3H3,(H,14,16)

tert-butyl (2-hydroxy-1-phenylethyl)carbamate - Physico-chemical Properties

Molecular Formula	C13H19NO3
Molar Mass	237.29
Density	1.101±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	141.0 to 147.0 °C
Boling Point	382.4±35.0 °C(Predicted)
Flash Point	185°C
Vapor Presure	1.57E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Yellow to Orange
pKa	11.55±0.46(Predicted)
Storage Condition	2-8°C
Refractive Index	1.523
MDL	MFCD01883039

tert-butyl (2-hydroxy-1-phenylethyl)carbamate - Introduction

tert-butyl (2-hydroxy-1-phenylethyl)carbamate is an organic compound with the chemical formula C16H23NO3. It mainly has the following properties:

1. Appearance: tert-butyl (2-hydroxy-1-phenylethyl)carbamate is a white crystalline solid.
2. Solubility: It can be dissolved in common organic solvents, such as methanol, ethanol, dimethylformamide, etc.
3. Melting point: The melting point of tert-butyl (2-hydroxy-1-phenylethyl)carbamate is 94-96°C.

The main use of tert-butyl (2-hydroxy-1-phenylethyl)carbamate is as an intermediate in organic synthesis. It can be used in the synthesis of a variety of organic compounds, particularly polypeptides. Because it has a protecting group (Boc group) in its structure, it can protect the amino group so that it can be selectively modified when necessary. Therefore, it has a wide range of applications in peptide synthesis, drug research and other fields.

The method for preparing tert-butyl (2-hydroxy-1-phenylethyl)carbamate is generally obtained by reacting phenylglycinol with t-butyl chloroformate. During the reaction, phenylglycinol and tert-butyl chloroformate are added into the reaction flask, and reacted under the action of an auxiliary catalyst (such as dimethylamine) to generate the target product. Finally, the tert-butyl (2-hydroxy-1-phenylethyl)carbamate is obtained by crystallization or column chromatography purification.

Regarding its safety information, tert-butyl (2-hydroxy-1-phenylethyl)carbamate are generally not significantly toxic under normal operating conditions. However, as an organic compound, it may still have some irritating and harmful effects on the human body. During use, you should wear appropriate protective equipment, such as laboratory gloves, safety glasses, etc., to avoid direct contact with skin and eyes.

Last Update：2024-04-09 21:54:55