tert-butyl (3-amino-3-thioxopropyl)carbamate

tert-butyl (3-amino-3-thioxopropyl)carbamate - Names and Identifiers

Name	tert-butyl N-(3-amino-3-thioxopropyl)carbamate
Synonyms	Ethyl 2-(1,3-thiazol-4-yl)acetate 3-Aminothiopropanamide, N3-BOC protected TERT-BUTYL-2-THIOCARBAMOYLETHYLCARBAMATE tert-butyl3-amino-3-thioxopropylcarbamate 3-(TERT-BUTOXYCARBONYLAMINO)THIOPROPIONAMIDE tert-butyl (3-amino-3-thioxopropyl)carbamate tert-butyl N-(3-amino-3-thioxopropyl)carbamate 3-[(tert-Butoxycarbonyl)amino]propanethioamide TERT-BUTYL N-(3-AMINO-3-THIOXOPROPYL)CARBAMATE (2-THIOCARBAMOYLETHYL)CARBAMIC ACID TERT-BUTYL ESTER
CAS	77152-97-7
EINECS	604-604-1
InChI	InChI=1/C8H16N2O2S/c1-8(2,3)12-7(11)10-5-4-6(9)13/h4-5H2,1-3H3,(H2,9,13)(H,10,11)

tert-butyl (3-amino-3-thioxopropyl)carbamate - Physico-chemical Properties

Molecular Formula	C8H16N2O2S
Molar Mass	204.29
Density	1.124±0.06 g/cm3(Predicted)
Melting Point	108-112
pKa	12.31±0.46(Predicted)
Refractive Index	1.52

tert-butyl (3-amino-3-thioxopropyl)carbamate - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
Hazard Note	Irritant

tert-butyl (3-amino-3-thioxopropyl)carbamate - Introduction

tert-butyl N-(3-amino-3-thioxopropyl)carbamate is an organic compound with the chemical formula C8H16N2O2S. The following is a description of its nature, use, preparation and safety information:

Nature:
1. Appearance: colorless crystal or white crystalline powder;
2. Solubility: Soluble in some organic solvents such as ether, alcohol, chlorinated hydrocarbon, etc;
3. Stability: relatively stable at room temperature, but decomposition may occur when encountering strong alkali or strong acid;
4. melting point: about 25-28 degrees Celsius.

Use:
1. tert-butyl N-(3-amino-3-thioxopropyl)carbamate can be used as substrates and intermediates in organic synthesis reactions, and can be used to synthesize other compounds;
2. It can also be used to prepare biologically active molecules, such as drugs.

Preparation Method:
A common preparation method of tert-butyl N-(3-amino-3-thioxopropyl)carbamate is obtained by the following reaction:
First, mix the nitrogen heterocyclic band and tripropylamine, and add dialkyl carbonate chloride (such as tert-butyl carbonyl chloride);
Next, the target product is obtained by carrying out the reaction under appropriate conditions of temperature and reaction time.

Safety Information:
1.tert-butyl N-(3-amino-3-thioxopropyl)carbamate should avoid contact with strong acid, strong alkali and other chemicals during use and storage, so as not to cause dangerous reactions;
2. It is a combustible substance, you should pay attention to fire prevention measures when handling, and operate in a well-ventilated place;
3. Data on potential hazards and toxicity to humans are currently limited, so proper laboratory procedures should be followed and appropriate protective equipment should be worn.

Last Update：2024-04-09 21:01:54