tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate - Names and Identifiers
Name | tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
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Synonyms | 4-AMino-1-Boc-3,3-difluor... 1-Boc-4-amino-3,3-difluoropiperidine 4-AMino-1-Boc-3,3-difluoropiperidine 1-N-Boc-4-amino-3,3-difluoro-piperidine tert-butyl 4-amino-3,3-difluoropiperidin tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate tert-butyl 4-aMino-3,3-difluoropiperidine-1-carboxylate 4-Amino-3,3-difluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 1-Piperidinecarboxylic acid, 4-aMino-3,3-difluoro-, 1,1-diMethylethyl ester
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CAS | 1255666-48-8
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tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate - Physico-chemical Properties
Molecular Formula | C10H18F2N2O2
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Molar Mass | 236.26 |
Density | 1.17±0.1 g/cm3(Predicted) |
Boling Point | 281.5±40.0 °C(Predicted) |
pKa | 7.66±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Sensitive | Irritant |
MDL | MFCD16250242 |
tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate - Introduction
tert-Butyl 4-amino-3, is an organic compound whose chemical formula is C9H17F2N2O2.
Properties: tert-Butyl 4-amino-3, with colorless or yellowish crystals or powder morphology. Its melting point is about 72-75 degrees Celsius. The compound exhibits solubility when dissolved in ethers, alcohols and organic solvents.
Purpose: tert-Butyl 4-amino-3, commonly used in the field of pharmaceutical research, as an important intermediate. It can be used to synthesize various bioactive molecules or to prepare drug candidate compounds.
preparation method: tert-Butyl 4-amino-3, the synthesis can be carried out in a variety of ways. One of the common synthesis methods is to obtain 4-amino -3, 3-difluoropiperidine from the reaction of 3,3-difluoro-4-chloropiperidine and tert-butyryl chloride, and then to carry out esterification reaction in the presence of di-tert-butyl carbonate to obtain the corresponding esterified product.
Safety information: For tert-Butyl 4-amino-3, safety data are rarely reported, so it is necessary to take necessary safety measures when using or handling this compound. Operate properly, wear protective gloves and glasses, and ensure that you work under well-ventilated conditions. In addition, avoid contact with skin, eyes and respiratory tract. If accidental contact occurs, immediately flush the affected area with plenty of water and seek medical help if necessary. It is best to store the compound in a sealed container, away from the fire and oxidant.
Last Update:2024-04-09 21:32:53