trans-4-(Methylamino)cyclohexanol hydrochloride

Name	trans-4-(Methylamino)cyclohexanol hydrochloride
Synonyms	trans-4-(Methylamino)cyclohexanol HCl trans-4-(Methylamino)cyclohexanol hydrochloride
CAS	923023-08-9

Molecular Formula	C7H16ClNO
Molar Mass	165.66104
Storage Condition	Inert atmosphere,Room Temperature

preparation	trans-4-(methylamino) cyclohexanol hydrochloride was prepared as follows: 2g of 2,2, 2-trifluoro-n-(4-hydroxy-cyclohexyl)-N-methyl-acetamide (149) was suspended in 10ml of 1N HCl and heated at 150 ° in a microwave oven until complete conversion. The resulting solution was lyophilized and the residue was placed in water and lyophilized again twice to give 150g of trans-4-(methylamino) cyclohexanol hydrochloride. Rt = 0.13min (method C). Test quality: 130.3(M H).
Application	trans-4-(methylamino) cyclohexanol hydrochloride is useful as a pharmaceutical synthesis intermediate. It can be prepared from 2,2, 2-trifluoro-n-(4-hydroxy-cyclohexyl)-N-methyl-acetamide in one step.
Use	trans-4-(methylamino) cyclohexanol hydrochloride can be used as a pharmaceutical synthesis intermediate, such as the preparation of the following compounds, for the preparation of Rho-kinase inhibitors. Use of the invention for the treatment of diseases associated with inhibition of myosin light chain phosphatase phosphorylation.

Last Update：2024-04-09 20:52:54