trans-Carboxy Glimepiride-d5 - Names and Identifiers
trans-Carboxy Glimepiride-d5 - Physico-chemical Properties
Molecular Formula | C24H32N4O7S
|
Molar Mass | 520.59848 |
Melting Point | 172-182°C |
Solubility | DMSO, Methanol (Sparingly) |
Appearance | Solid |
Color | Off-White |
Storage Condition | -20°C Freezer |
trans-Carboxy Glimepiride-d5 - Introduction
trans-Carboxy Glimepiride-d5 is a pharmaceutically active compound that is a metabolite of the blood glucose regulating drug glimepiride. The following is a description of the properties, uses, preparation and safety information of the compound:
Properties: trans-Carboxy Glimepiride-d5 is a white crystalline solid at room temperature and can be dissolved in organic solvents such as chloroform and methanol. The chemical structure of the compound contains the backbone of glimepiride and contains five deuterium atoms, the presence of which can be confirmed by mass spectrometry techniques.
Purpose: trans-Carboxy Glimepiride-d5 is commonly used in pharmacokinetic studies to study the absorption, distribution, metabolism and excretion of glimepiride in the body. By using this compound as an internal standard, the rate and pathway of glimepiride metabolism can be accurately determined.
Preparation method: The preparation of trans-Carboxy Glimepiride-d5 involves isotope labeling of glimepiride. A common preparation method is to react glimepiride with a reducing agent containing deuterium gas to replace the hydrogen atoms in glimepiride with deuterium atoms. The trans-Carboxy Glimepiride-d5 compound with high purity can be obtained by an appropriate purification step.
Safety information: There are relatively few studies on the safety of trans-Carboxy Glimepiride-d5. When handling and using the compound, it is necessary to follow general laboratory safety practices, such as wearing protective gloves, eye protection and ventilation. In addition, depending on the requirements of the laboratory, it may be necessary to store and handle under certain conditions. If the compound is used in clinical trials or for human use, it is necessary to follow relevant regulations and regulations, and to fully understand its toxicity and drug interaction information. In all cases, the use of drugs and chemicals should be carried out under professional guidance.
Last Update:2024-04-09 15:18:06