trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate - Names and Identifiers
trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate - Physico-chemical Properties
trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate - Introduction
trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate is an organic compound with the chemical formula C12H13NO4.
Properties: trans-ethyl -2-(4-nitrophenyl) cyclopane -1-carboxylate is a colorless liquid. Its melting point and boiling point are 72-73°C and 202-203°C, respectively. This compound can be dissolved in some organic solvents, such as alcohols, ethers and aromatic hydrocarbons.
Purpose: trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate is commonly used as a synthetic drug intermediate, such as for the synthesis of anti-tumor drugs. It can also be used in organic synthesis reactions such as olefin cyclization and aromatization reactions.
preparation method: trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate can be synthesized by the reaction of cyclopropane and nitroacetophenone. The specific preparation steps are as follows: first, nitroacetophenone is reacted with ethyl ethyl acetate to obtain nitrophenylethyl acetate. Then, reaction with acetone hydrocyanate in the presence of ursolic acid gives 1-[(2-cyano-1-methyllethoxy) carbonyl]-2-(4-nitrophenyl)cyclopropane. Finally, the obtained product is reacted with acetic acid to obtain the target product.
Safety Information: trans-ethyl -2-(4-nitrophenyl)cyclopropane-1-carboxylate is generally stable and safe under normal industrial conditions of use. However, it is a flammable liquid and should be kept away from fire and oxygen. Pay attention to protective measures during operation, such as wearing appropriate protective glasses and gloves. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. In addition, ensure good ventilation during use.
Last Update:2024-04-09 21:00:56