ChemBK
  • Home
  • Product Category

tripiperazine dicitrate

citric acid sesquipiperazine salt

CAS: 144-29-6

Molecular Formula: C24H46N6O14

  1. Home
  2. Product Category
  3. intermediate
  4. pharmaceutical intermediates
  5. tripiperazine dicitrate

tripiperazine dicitrate - Names and Identifiers

Name citric acid sesquipiperazine salt
Synonyms ANTEPAR
PARAZINE
PIPERAZINE CITRATE
Piperazine citrate
PiperazineCitrateBp
Tripiperazindicitrat
tripiperazine dicitrate
TRIPIPERAZINE DICITRATE
PIPERAZINE CITRATE SALT
citric acid sesquipiperazine salt
CITRIC ACID SESQUIPIPERAZINE SALT
CAS 144-29-6
EINECS 205-622-8
InChI InChI=1S/2C6H8O7.3C4H10N2/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;3*1-2-6-4-3-5-1/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);3*5-6H,1-4H2

tripiperazine dicitrate - Physico-chemical Properties

Molecular FormulaC24H46N6O14
Molar Mass642.65
Density0.741[at 20℃]
Melting Point183-187℃
Boling Point208℃[at 101 325 Pa]
Water Solubility54g/L at 24℃
Vapor Presure56.928Pa
AppearanceCrystal
ColorWhite to Almost white
Merck14,7464
Storage ConditionInert atmosphere,Room Temperature
MDLMFCD00038961
Physical and Chemical Properties

UseUsed as an anti-helminth drug

tripiperazine dicitrate - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany1
RTECSTL3485000
HS Code29335990

tripiperazine dicitrate - Standard

Authoritative Data Verified Data

This product is calculated as anhydrous, containing (C4H10N2)3 • 2C6H807 not less than 98.5%.

Last Update：2024-01-02 23:10:35

tripiperazine dicitrate - Trait

Authoritative Data Verified Data
  • This product is a white crystalline powder or translucent crystalline particles; Odorless; Micro-hygroscopicity.
  • This product is soluble in water, very slightly soluble in methanol, insoluble in ethanol, chloroform, ether or petroleum ether.
Last Update：2022-01-01 13:38:59

tripiperazine dicitrate - Differential diagnosis

Authoritative Data Verified Data
  1. take about 0.lg of this product, add 5ml of water to dissolve, add 0.5g of sodium bicarbonate, of potassium ferricyanide solution and 1 drop of Mercury, shake strongly for 1 minute, and place it above 20C for about 20 minutes, gradually appearing red.
  2. the aqueous solution of this product shows the identification reaction of citrate (General rule 0301).
Last Update：2022-01-01 13:39:00

tripiperazine dicitrate - Exam

Authoritative Data Verified Data

first amine with ammonia

take 0.50g of this product, Add 10ml of water and 10% ml of 1.0 sodium hydroxide solution, shake to dissolve, add 1.0ml of acetone and ml of sodium nitrosoferricyanide solution, mix well, and place it accurately for 10 minutes; the same amount of reagent was taken separately, but water was used instead of the 10% sodium hydroxide solution as a blank. The absorbance was measured at wavelengths of 0401 nm and Nm respectively according to UV-visible spectrophotometry (general rule). The ratio of the absorbance at a wavelength of 600nm to the absorbance at a wavelength of 520nm should not be more than 0.50 (equivalent to about 0.1% of the first amine and ammonia).

moisture

take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 10.0% ~ 14.0%.

ignition residue

not more than 0.1% (General rule 0841).

Iron Salt

take 2.og of this product, add water 35ml and hydrochloric acid 3ml to dissolve, add ammonium persulfate 50mg and ammonium thiocyanate solution (30-100)3ml, then add appropriate amount of water to make 50ml, shake well, add butanol 20ml, after extraction by shaking, after placing them into layers, the butanol layer shall be separated and taken out. In case of color development, the butanol layer shall not be deeper (0.0005%) compared with of standard iron solution prepared by the same method.

Heavy metals

take this product 2. G, add water dissolved in 0821, add dilute hydrochloric acid 4. OML, inspection according to law (general principles the first law), containing heavy metals shall not exceed 10 parts per million.

Last Update：2022-01-01 13:39:01

tripiperazine dicitrate - Content determination

Authoritative Data Verified Data

take this product about 0.lg, precision weighing, add glacial acetic acid 30ml, shake to dissolve, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 10.71mg(C4H10N2)3.2C6H80.

Last Update：2022-01-01 13:39:01

tripiperazine dicitrate - Category

Authoritative Data Verified Data

anti-worm drugs.

Last Update：2022-01-01 13:39:02

tripiperazine dicitrate - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 13:39:02

tripiperazine dicitrate - Piperazine citrate tablets

Authoritative Data Verified Data

This product contains piperazine citrate [(C4H10N2)3 • 2C6H807 • 5H20] should be 93.0% ~ 107.0% of the label amount.

trait

This product is white tablet.

identification

take an appropriate amount of fine powder of this product (about 0.5g equivalent to piperazine citrate), add water 20ml, shake to dissolve piperazine citrate, filter, filtrate under the identification test of piperazine citrate, the same reaction was shown.

examination

should be in accordance with the relevant provisions under The tablet item (General rule 0101).

Content determination

Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about equivalent to piperazine citrate O.lg ), according to the method for the determination of piperazine citrate. Each 1 ml of perchloric acid titration solution (0.1mol/L) corresponds to 12.21mg of (C4H10N2)3.2C6H807.5H20.

category

with piperazine citrate.

specification

(1)0.25g (2)0.5g

storage

light shielding, sealed storage.

Last Update：2022-01-01 13:39:03

tripiperazine dicitrate - Piperazine citrate syrup

Authoritative Data Verified Data

This product contains piperazine citrate [(C4H10N2)3 • 2C6H807 • 5H20] should be 14.4% ~ 17.6% (g/ml).

trait

This product is a clear thick liquid; With an aromatic odor of flavoring.

identification

3ml of this product was diluted with 2ml of water, and then the same reaction was shown according to the identification (1) Test under piperazine citrate.

examination

  • relative density the relative density of this product (General 0601) should be 1.270-1.305.
  • others shall comply with the relevant provisions under syrup (General rule 0116).

Content determination

take 5ml of this product with a volume pipette, put it in a 50ml measuring flask, wash out the attached liquid on the inner wall of the pipette with a small amount of water, wash it into the measuring flask, dilute it with water to the scale, shake well, take 10ml accurately, put it in a 150ml beaker, add 70ml trinitrophenol test solution, stir, heat, clarify the upper layer solution, let it cool, after 1 hour, after filtering through a vertical melting glass crucible of constant weight at 105°C, the precipitate is washed several times with a saturated solution of a trinitrophenol derivative of piperazine (C4Hl0N2 • 2C6H3N307) and dried at 105°C to constant weight, precision weighing, the weight of the precipitate is multiplied by 0.4487, that is, the weight of the test quantity containing (C4H10N2)3 • 2C6H807 • 5H20.

category

with piperazine citrate.

storage

light shielding, sealed storage.

Last Update：2022-01-01 13:39:03

tripiperazine dicitrate - Reference Information

LogP-1.15
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Biological activity Piperazine citrate is a six-membered ring compound, originally used as an insect repellent.
use intestinal insect repellent, used for pinworm and roundworm infection.
Used as anti-worm drug
production method dissolve piperazine hexahydrate in distilled water, add activated carbon to decolorise at 50-60 ℃ for half an hour, and filter. The citric acid was added to the filtrate and stirred at 88-90 ℃ for 1.5 hours. Cool to 35 ℃, add ethanol, cool and crystallize, spin and filter, and dry to obtain the finished product.
Last Update：2024-04-09 21:21:28
tripiperazine dicitrate
Supplier List
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: citric acid sesquipiperazine salt Request for quotation
CAS: 144-29-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Piperazine Citrate Visit Supplier Webpage Request for quotation
CAS: 144-29-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: citric acid sesquipiperazine salt Request for quotation
CAS: 144-29-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Piperazine Citrate Visit Supplier Webpage Request for quotation
CAS: 144-29-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
tripiperazine dicitrate
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001