trisodium citrate anhydrous
Sodium citrate, anhydrous
CAS: 68-04-2
Molecular Formula: C6H5Na3O7
trisodium citrate anhydrous - Names and Identifiers
| Name | Sodium citrate, anhydrous |
| Synonyms | Sodium citrate Trisodium citrate Sodium citrate, tribasic anhydrous Sodium Citrate Sodium Citrate anhydrous Sodium citrate, anhydrous trisodium citrate anhydrous trisodium 2-hydroxypropane-1,2,3-tricarboxylate anhydrous |
| CAS | 68-04-2 |
| EINECS | 200-675-3 |
| InChI | InChI=1/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 |
| InChIKey | HRXKRNGNAMMEHJ-UHFFFAOYSA-K |
trisodium citrate anhydrous - Physico-chemical Properties
| Molecular Formula | C6H5Na3O7 |
| Molar Mass | 258.07 |
| Density | 1.008 g/mL at 20 °C |
| Melting Point | 300°C |
| Boling Point | 309.6°C at 760 mmHg |
| FEMA | 3026 | SODIUM CITRATE |
| Flash Point | 155.2°C |
| Water Solubility | Soluble in water. |
| Solubility | Soluble in water, insoluble in ethanol |
| Vapor Presure | 5.73E-05mmHg at 25°C |
| Appearance | White crystalline particles or powder |
| Color | White to off-white |
| Maximum wavelength(λmax) | λ: 260 nm Amax: ≤0.1 |
| PH | 8.59(1 mM solution);8.9(10 mM solution);9.04(100 mM solution);9.26(1000 mM solution) |
| Storage Condition | 2-8℃ |
| Sensitive | Hygroscopic |
| MDL | MFCD00012462 |
trisodium citrate anhydrous - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect R48/20/22 - R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R36 - Irritating to the eyes R35 - Causes severe burns |
| Safety Description | S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 2 |
| RTECS | GE8300000 |
| FLUKA BRAND F CODES | 34 |
| TSCA | Yes |
| HS Code | 29181500 |
| Toxicity | LD50 in rats, mice (mmol/kg): 6.0, 5.5 i.p. (Gruber, Halbeisen) |
trisodium citrate anhydrous - Upstream Downstream Industry
| Downstream Products | 4,6-Dimethylpyrimidine-5-carboxylic acid FERRIC CITRATE |
trisodium citrate anhydrous - Reference
| Reference Show more | 1. Xiong Wei, Zhao Yan, Cheng Jinjun, etc. Study on the discovery of new type carbon dots and its hemostatic effect in the covid-19 [J]. Chinese herbal medicine, 2019, 50(06):1388-1394. 2. Ren Xi-Bo Dai Xi-Yao Zhang Junhua et al. Study on the difference of amylase activity in different radish varieties [J]. Northern horticulture 2012(22):21-23. 3. Wang Changfeng, Cong Zhu Feng, Liu Guofei, Wang Shaoping, to Zedong, Dong Pingping, Sun Ping, Zhao Hongjin, Gao Peng, dailong. Effects of different processed Leech products on Hemorheology and coagulation indexes in rats with acute blood stasis [J]. China Pharmacy, 2020,31(16):1984-1988. 4. Qinyuan Hong, Haomiao Xu, Jixing Li, Wenjun Huang, Ping Liu, Zan Qu, Naiqiang Yan, shell-thickness, Volume 420, Part 2, 2021 5. [IF=6.291] Fei Zhou et al."Assessment of speciation and in vitro bioaccessibility of selenium in Se-enriched Pleurotus ostreatus and potential health risks."Ecotox Environ Safe. 2019 Dec;185:109675 6. [IF=5.833] Jiang Xiaowen et al."Colorimetric and fluorometric dual-channel ratiometric determination of fungicide cymoxanil based on analyte-induced aggregation of silver nanoparticles and dually emitting carbon dots."Microchim Acta. 2019 Aug;186(8):1-12 7. [IF=4.39] Cailing Jiang et al."Highly uniform self-assembled monolayers of silver nanospheres for the sensitive and quantitative detection of glutathione by SERS."Dalton T. 2021 Aug;50(30):10436-10445 8. [IF=3.517] Juan Wu et al."pH-sensitive magnetic drug delivery system via layer-by-layer self-assembly of CS/PEG and its controlled release of DOX."J Biomat Sci-Polym E. 2020;31(8):1057-1070 9. [IF=3.361] Fengyi Cao et al."Synthesis of photothermal antimicrobial cotton gauze using AuNPs as photothermal transduction agents."Rsc Adv. 2021 Jul;11(42):25976-25982 10. [IF=10.618] Mei Li et al."A visual peroxidase mimicking aptasensor based on Pt nanoparticles-loaded on iron metal organic gel for fumonisin B1 analysis in corn meal."Biosens Bioelectron. 2022 Aug;209:114241 |
trisodium citrate anhydrous - Standard
Authoritative Data Verified Data
This product is 2-hydroxypropane-1, 2, 3-tricarboxylic acid sodium dihydrate. Calculation, containing C6H5Na307 not less than 99.0%.
Last Update：2024-01-02 23:10:35
trisodium citrate anhydrous - Trait
Authoritative Data Verified Data
- This product is colorless crystal or white crystalline powder; Odorless; Slightly deliquescent in wet air and weathered in hot air.
- This product is soluble in water and insoluble in ethanol.
Last Update：2022-01-01 13:39:04
trisodium citrate anhydrous - Introduction
Correct the acidity of urine. Polyvalent complexing agent, a polyvalent chelating agent that removes trace metals. Buffer, bacterial medium.
Last Update：2022-10-16 17:27:52
trisodium citrate anhydrous - Differential diagnosis
Authoritative Data Verified Data
The Goods Show the identification of sodium salt and citrate reaction (General 0301).
Last Update：2022-01-01 13:39:04
trisodium citrate anhydrous - Exam
Authoritative Data Verified Data
alkalinity
take l.Og of this product, add 20ml of water to dissolve, add 1 drop of phenolphthalein indicator solution and 0.05 ml of sulfuric acid titration solution (0.10 mol/L), and do not appear red. The clarity and color of the solution take this product 2.5g, add water 10ml after dissolution, the solution should be clear and colorless.
chloride
take 0.60g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0ml of standard sodium chloride solution, it should not be more concentrated (0.01%).
sulfate
take 0.50g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.05% of standard potassium sulfate solution, it should not be more concentrated ().
tartrate
Take lg of this product, put it in a test tube, add 2ml of water to dissolve it, add 1ml of potassium acetate test solution and acetic acid respectively, and rub the tube wall with a glass rod to prevent precipitation of crystalline precipitate.
easily carbonized
take 0.40g of this product, add 5ml of sulfuric acid (containing H2S04 94.5% ~ 95.5%), heat at 90°C ± 1°C for 1 hour, immediately cool down, and check according to law (General rule 0842), it should not be deeper than the yellow or yellow-green standard colorimetric solution No. 8.
loss on drying
take this product, dry to constant weight at 180°C, weight loss should be 10.0% ~ 13.0% (General 0831).
calcium or oxalate
take 2.0g of this product, add 20ml of New boiling cold water to dissolve, add 0.4ml of ammonia test solution and 2ml of ammonium oxalate test solution, shake, and place for 1 hour, if turbidity occurs, add 0.125g of calcium carbonate to standard calcium solution, put it in a 500ml measuring flask, add 5ml of mixed solution of water and 0.5ml of hydrochloric acid to dissolve, dilute to the mark with water, and shake well, equivalent to mg of calcium (Ca) per 1 ml] 0.005% ml of the control solution should not be more concentrated (). In the above inspection, if there is no turbidity, should take the product l. Add the mixed solution of 1 ml of water and 3ml of dilute hydrochloric acid to dissolve, add 4 drops of 90% ethanol and 4ml of calcium chloride test solution, and let stand for 1 hour without turbidity.
Iron Salt
take 1.0g of this product and check it according to law (General rule 0807). After extracting with n-butanol, compare with 0.001% of standard iron solution and the control solution made by the same method.
Heavy metals
take 2.0g of this product, Add 10ml of water to dissolve, Add 10ml of dilute acetic acid and an appropriate amount of water to make 25ml, and check according to law (General rule 0821 first law), containing no more than 5 parts per million of heavy metals.
arsenic salt
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product and check it according to law (General rule 1143). The amount of endotoxin per 1 mg of sodium citrate should be less than 0.25EU. (For injection)
Last Update：2022-01-01 13:39:05
trisodium citrate anhydrous - Content determination
Authoritative Data Verified Data
take about 80mg of this product, precision weighing, add 5ml of glacial acetic acid, heat and dissolve, cool, add 10ml of acetic anhydride and crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 8.602mg of C6H5Na307.
Last Update：2022-01-01 13:39:06
trisodium citrate anhydrous - Category
Authoritative Data Verified Data
anticoagulant.
Last Update：2022-01-01 13:39:06
trisodium citrate anhydrous - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:39:06
trisodium citrate anhydrous - Sodium Citrate Injection for blood transfusion
Authoritative Data Verified Data
This product is a sterile aqueous solution of sodium citrate. The content of sodium citrate (C6H5Na307 • 2H20) shall be between 94.0% and 106.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
This product sodium salt identification (1) and identification of citrate reaction (General 0301).
examination
- the pH value should be 6.5 to 8.5 (General 0631).
- the bacterial endotoxin of this product shall be taken and checked according to law (General rule 1143), and the amount of endotoxin contained in 1 mg sodium glutamate shall be less than 0.25EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take 3ml of this product with precision, put it on a water bath, dry it at 105°C for 30 minutes, let it cool, and start from "add 5ml of glacial acetic acid" according to the method under sodium citrate, determination according to law. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 9.803mg of c6h5na307.2h20.
category
with sodium citrate.
specification
(l)lOml:0.25g (2) 160ml:6.4g (3) 180ml:7.2g (4) 200ml:8g
storage
sealed storage.
Last Update：2022-01-01 13:39:07
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