美托咪定杂质56

Name	Dexmedetomidine
Synonyms	MPV 1440 Precedex d-Medetomidine Dexmedetomidine UNII-67VB76HONO Dexmedetomidina (S)-Medetomidine Dexmedetomidinum Dexmedetomidinum [INN-Latin] Dexmedetomidina [INN-Spanish] Dexmedetomidinehclc13H16N2.Hcl DexmedetomidineHclC13H16N2.Hcl (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole 4-[(S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole 5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole Dexmedetomidine Hcl C13H16N2.Hcl 145108-58-3(Hcl) 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)- (+)-4-[(S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
CAS	113775-47-6
EINECS	601-281-8
InChI	InChI=1/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1

Molecular Formula	C13H16N2
Molar Mass	200.28
Density	1.053±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	146-149°C
Boling Point	381.9±11.0 °C(Predicted)
Flash Point	191.3°C
Vapor Presure	1.08E-05mmHg at 25°C
pKa	13.89±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.569
In vitro study	Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1, compared to 220:1 for clonidine) and is therefore considered to be a full agonist of the α2 receptor. This may lead to more effective sedation without the cardiovascular response caused by the activation of redundant α1 receptors. The 2-hour half-life of Dexmedetomidine is almost 4 times shorter than that of clonidine, which increases the possibility that continuous administration of dexmedetomidine is effective for sedation. Dexmedetomidine also has minimal alveolar anesthetic concentration (MAC)-retention properties, but its use as an anesthetic is complicated by persistent hypotension, intravenous infusion administration and vasopressor administration. In addition, its use in large doses is accompanied by a2-receptor mediated vasoconstriction caused by hypertension.