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Supplier NameMedChemExpress (MCE)
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Product Name6,4'-Dihydroxy-7-methoxyflavanone
Synonyms6,4'-Dihydroxy-7-methoxyflavanone
CAS189689-32-5
EINECS
Chemical FormulaC16H14O5
Molecular Weight286.28
inchi
Package1 mg
PriceEmail to quote
Descriptions6,4'-Dihydroxy-7-methoxyflavanone

6,4'-Dihydroxy-7-methoxyflavanone

MedChemExpress (MCE)

HY-N9736

189689-32-5

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

6,4'-Dihydroxy-7-methoxyflavanone

6,4'-Dihydroxy-7-methoxyflavanone

MedChemExpress (MCE)

HY-N9736

189689-32-5

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.

6,4'-Dihydroxy-7-methoxyflavanone (3-30 µM
macrophages) inhibits osteoclastogenesis and TRAP activity in a dose-dependent manner[1]. 6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM
48 h) disrupts actin ring formation of mature osteoclasts[1]. 6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM
1 h
macrophages) inhibits RANKL-induced expression of nuclear factor of activatied T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) and c-Fos via inhibition of mitogen activated protein kinases (MAPKs) pathway[1].

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[1]. Im NK, et, al. 6,4'-Dihydroxy-7-methoxyflavanone inhibits osteoclast differentiation and function. Biol Pharm Bull. 2013
36(5):796-801. [Content Brief]

Last Update2025-04-01 14:45:47
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