Protopine hydrochloride MedChemExpress (MCE)

Product Name	PROTOPINE HYDROCHLORIDE
Synonyms	FUMARINE;MACLEYINE;PROTOPINE HCL;Argemonine (protopine;FUMARINE HYDROCHLORIDE;PROTOPINE HYDROCHLORIDE
CAS	6164-47-2
EINECS	228-196-5
Chemical Formula	C20H20ClNO5
Molecular Weight	389.83
inchi
Package	1 mg
Price	Email to quote
Descriptions	Protopine hydrochloride Protopine hydrochloride MedChemExpress (MCE) HY-N0793A 6164-47-2 Corydinine hydrochloride Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Protopine hydrochloride Protopine hydrochloride MedChemExpress (MCE) HY-N0793A 6164-47-2 Corydinine hydrochloride Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity. Protopine (10-40 μM, 24 h-96 h) hydrochloride inhibits cell viability, migration, invasion and EMT process of liver carcinoma cells (HepG2, Huh7)[2].Protopine (10-40 μM, 24 h) hydrochloride induces apoptosis by increasing the expression of caspase-3 and caspase-9 in HepG2 and Huh7 cells, and inhibits the PI3K/Akt signaling pathway[2].Protopine (10-40 μM, 6 h) hydrochloride induces generation of ROS in HepG2 and Huh7 cells[2].Protopine (0-10 μg/mL) hydrochloride inhibits the uptake of serotonin transporter (SERT) in S6 cells and noradrenaline (NE) uptake in N1 cells[3]. Protopine (0.1 and 1 mg/kg, i.p.) hydrochloride alleviates Scopolamine (HY-N0296) (1 mg/kg)-induced memory impairment in mice[1].Protopine (5-20 mg/kg, i.v.) hydrochloride inhibits tumor growth and inhibits PI3K/Akt, and induces cleavage of caspase-3 in xenograft BALB/c mice (s.c. with HepG2 or Huh-7 cells)[2].Protopine (5-20 mg/kg, i.p.) hydrochloride shows antidepressant-like effect in mice HTR and TST tests[3].Protopine (1-4 mg/kg, i.p., once daily for 3 days) hydrochloride shows protective effect on the focal cerebral ischaemic induced injury in rats[4]. \| \| \| \| \| \| \| \| \| \| [1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr 65(3):218-21. [Content Brief] [2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27 21(1):396. [Content Brief] [3]. Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun 50(8):934-40. [Content Brief] [4]. Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug 101(2):85-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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