(+)-Erinacin A MedChemExpress (MCE)

Product Name	Erinacine A Erinacin A
Synonyms	(+)-Erinacin A;Erinacine A Erinacin A;Cyclohept[e]indene-8-carboxaldehyde, 2,3,3a,4,5,5a,6,7-octahydro-3a,5a-dimethyl-1-(1-methylethyl)-6-(β-D-xylopyranosyloxy)-, (3aR,5aR,6S)-
CAS	156101-08-5
EINECS
Chemical Formula	C25H36O6
Molecular Weight	432.55
inchi
Package	1 mg
Price	Email to quote
Descriptions	(+)-Erinacin A (+)-Erinacin A MedChemExpress (MCE) HY-111954 156101-08-5 Erinacine A 99.97% -20°C, protect from light In solvent : -80°C, 6 months Descriptions (+)-Erinacin A (+)-Erinacin A MedChemExpress (MCE) HY-111954 156101-08-5 Erinacine A 99.97% -20°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. (+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage. (+)-Erinacin A (30 μM 3-24 h) activates the extrinsic and intrinsic apoptosis pathways in DLD-1 cells and reduces the expression of anti-apoptotic proteins[4]. (+)-Erinacin A (1, 5 and 10 mg/kg, i.p. single dose) inhibits neuronal cell death in SAM rats with transient stroke and suppresses the expression of inflammatory cytokines in SAM brain tissues with transient stroke[4]. (+)-Erinacin A (1, 2 and 5 mg/kg, i.p. once a day for 5 days) significantly reduces tumor volume in DLD-1 xenograft mice[5]. \| \| \| \| \| \| \| \| \| \| [1]. Bailly C, et.al. Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res. 2020 Sep 159:104953. [Content Brief] [2]. Tsai-Teng T, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice[J]. Journal of biomedical science, 2016, 23: 1-12. [Content Brief] [3]. Prasher P, et al. Key oncologic pathways inhibited by Erinacine A: a perspective for its development as an anticancer molecule[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114332. [Content Brief] [4]. Lee K F, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine[J]. International journal of molecular sciences, 2014, 15(9): 15073-15089. [Content Brief] [5]. Lee K C, et al. Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, Fas, and Fas ligand via the JNK/p300/p50 signaling pathway with histone acetylation[J]. Frontiers in Pharmacology, 2019, 10: 1174. [Content Brief]
Last Update	2025-04-01 14:45:47

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