6PPD-Q MedChemExpress (MCE)

Product Name	2,5-Cyclohexadiene-1,4-dione, 2-[(1,3-dimethylbutyl)amino]-5-(phenylamino)-
Synonyms	2,5-Cyclohexadiene-1,4-dione, 2-[(1,3-dimethylbutyl)amino]-5-(phenylamino)-;2-((4-methylpentan-2-yl)amino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione
CAS	2754428-18-5
EINECS
Chemical Formula	C18H22N2O2
Molecular Weight	298.38
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	6PPD-Q 6PPD-Q MedChemExpress (MCE) HY-153169 2754428-18-5 6PPD-Quinone 99.30% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 6PPD-Q 6PPD-Q MedChemExpress (MCE) HY-153169 2754428-18-5 6PPD-Quinone 99.30% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders. 6PPD-Q (10 nM, 100 nM, 7 days) increases α-syn aggregation in primary dopaminergic neurons, enhances α-syn PFF-induced p-α-synSer129 expression, and promotes its accumulation in mitochondria[2].6PPD-Q (10 nM, 100 nM, 7 days) reduces mitochondrial respiration in primary dopaminergic neurons, particularly under α-syn PFF (α-synuclein preformed fibrils) treatment conditions[2].6PPD-Q (10 nM, 100 nM, 7 days) decreases glycolysis metabolites and alters TCA cycle intermediates in primary dopaminergic neurons, leading to a reduction in glycolysis metabolites (e.g., fructose-6-phosphate, pyruvate) and TCA cycle intermediates (e.g., citrate, α-ketoglutarate)[2].6PPD-Q (10 nM, 100 nM, 48 hours) does not exhibit significant cytotoxicity in primary dopaminergic neurons[2]. 6PPD-Q (0.1, 1, 10, 100 μg/kg, p.o., once daily for 21 days) induces intestinal injury in ICR mice, characterized by increased inflammatory response in the jejunum and ileum and impaired intestinal barrier integrity[3]. CB1 CB2 ACAT-1 A2AR \| \| \| \| \| \| \| \| \| \| [1]. Du B, et al. First report on the occurrence of N-(1, 3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from south China. Environ Sci Technol Lett, 2022, 9(12): 1056-1062. [2]. Fang J, et al. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding. J Hazard Mater. 2024 Mar 5 465:133312. [Content Brief] [3]. Yang Y, et al. Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation[J]. Science of The Total Environment, 2024, 918: 170679. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Glycyl-L-glutamine

Category: Natural Products
CAS: 13115-71-4
Last Update: 2025-04-01 14:45:47

Triose phosphate

Category: Natural Products
CAS: 591-57-1
Last Update: 2025-04-01 14:45:47

Lactyl-CoA

Category: Natural Products
CAS: 1926-57-4
Last Update: 2025-04-01 14:45:47

12(S)-HPETE

Category: Natural Products
CAS: 71774-10-2
Last Update: 2025-04-01 14:45:47

Pyrithiamine

Category: Natural Products
CAS: 534-64-5
Last Update: 2025-04-01 14:45:47

alpha-CEHC

Category: Natural Products
CAS: 4072-32-6
Last Update: 2025-04-01 14:45:47

Maltoheptaose

Category: Natural Products
CAS: 34620-78-5
Last Update: 2025-04-01 14:45:47

Phenoxyethanol

Category: Natural Products
CAS: 122-99-6
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact