Conglobatin MedChemExpress (MCE)

Product Name	CONGLOBATIN
Synonyms	CONGLOBATIN
CAS	72263-05-9
EINECS
Chemical Formula	C28H38N2O6
Molecular Weight	498.61
inchi
Package	500 μg
Price	Email to quote
Descriptions	Conglobatin Conglobatin MedChemExpress (MCE) HY-119906 72263-05-9 FW-04-806 95.48% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Conglobatin Conglobatin MedChemExpress (MCE) HY-119906 72263-05-9 FW-04-806 95.48% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo. Conglobatin (6.25-100 μM 48 h) markedly inhibits the proliferation of SKBR3 and MCF-7 cells, with IC50s of 12.11 and 39.44 μM, respectively[2]. Conglobatin inhibits cell proliferation in EC109, KYSE70, KYSE450, KYSE150, KYSE180, and KYSE510 cells, with IC50s of 16.43, 15.89, 10.94, 10.50, 10.28, and 9.31 μM, respectively[3]. Conglobatin (10-40 μM 24 h) displays obvious arrest of SKBR3 and MCF-7 cells in the G2/M phase. Conglobatin induces apoptosis through caspase-dependent pathways in SKBR3 and MCF-7 cells[2]. Conglobatin (10-40 μM 3-24 h) reduces Hsp90 client protein levels and induces proteasome-dependent degradation[2]. Conglobatin binds to the N-terminal of Hsp90, does not affect ATP-binding capability of Hsp90, but inhibits Hsp90/Cdc37 chaperone/co-chaperone interactions[2]. Conglobatin (50-200 mg/kg i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2]. Conglobatin (4-8 mg/kg i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3] HSP90 \| \| \| \| \| \| \| \| \| \| [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep 32(9):874-7. [Content Brief] [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14 13:150. [Content Brief] [3]. Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30 6(18):15940-52. [Content Brief]
Last Update	2025-04-01 14:45:47

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