d-Sophoridine MedChemExpress (MCE)

Product Name	sophoridine
Synonyms	6β-Matrine;sophoridine;ALLOMATRINE;allomatrine;6-Allomatrine;Tetrahydroisosophoramine;Allomatrine 6-Allomatrine;4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
CAS	83148-91-8;6882-68-4;641-39-4
EINECS
Chemical Formula	C15H24N2O
Molecular Weight	248.36
inchi	InChI=1/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+/m1/s1
Package	5 mg
Price	Email to quote
Descriptions	d-Sophoridine d-Sophoridine MedChemExpress (MCE) HY-N1373A 83148-91-8 (+)-Sophoridine Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions d-Sophoridine d-Sophoridine MedChemExpress (MCE) HY-N1373A 83148-91-8 (+)-Sophoridine Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity. Sophoridine (0-500 μM 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM[1]. Sophoridine (0-20 μM 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively[1]. Sophoridine (0-20 μM 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio[1]. Sophoridine (intraperitoneal injection 20 or 40 mg/kg 21 days) can inhibit the growth of xenograft pancreatic tumors[1]. \| \| \| \| \| \| \| \| \| \| [1]. Xu Z, et al. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11 36(1):124. [Content Brief]
Last Update	2025-04-01 14:45:47

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