Peruvoside MedChemExpress (MCE)

Product Name	Peruvoside
Synonyms	Enordin Pervoside PERUVOSIDE Peruvoside (22)-enolide Cannogenin α-L-thevetoside (3β,5β)-3-(6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxyl)-14-hydroxy-19-oxocard-20(22)-enolide Synonyms Enordin Pervoside PERUVOSIDE Peruvoside (22)-enolide Cannogenin α-L-thevetoside (3β,5β)-3-(6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxyl)-14-hydroxy-19-oxocard-20(22)-enolide (3β,5β)-3-[(6-Deoxy-3-O-Methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-19-oxocard-20(22)-enolide 3β-[(6-Deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-19-oxo-5β,14β-card-20(22)-enolide
CAS	1182-87-2
EINECS	214-659-9
Chemical Formula	C30H44O9
Molecular Weight	548.66
inchi
Package	1 mg
Price	Email to quote
Descriptions	Peruvoside Peruvoside MedChemExpress (MCE) HY-108016 1182-87-2 Encordin 99.32% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Peruvoside Peruvoside MedChemExpress (MCE) HY-108016 1182-87-2 Encordin 99.32% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib. Peruvoside (50-1000 nM, 24 h) inhibits the viability and proliferation in PC9, PC9/gef, H3255, and H1975 cell lines[1]. Peruvoside (0.005-0.5 μM, 72 h) sensitizes A549, PC9/gef and H1975 to Gefitinib when in combination with Gefitinib (0.01~0.5 μM)[1]. Peruvoside (0-100 μM, 24 h) induces cell cycle arrest and apoptosis in MCF-7, HpG2, and A549 cells[2. Peruvoside (0.1 mg/kg for i.p once daily for 28 days) suppresses the tumour growth in lung cancer mice model[1]. Peruvoside (0.59 mg/kg for i.p once daily for 7 days) reduces mortality in EV-A71-infected mice model[4]. \| \| \| \| \| \| \| \| \| \| [1]. Lai Y, et al. Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways. Am J Cancer Res. 2022 Jun 15 12(6):2576-2593. [Content Brief] [2]. Reddy D, et al. Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers. Life Sci. 2020 Jan 15 241:117147. doi: 10.1016/j.lfs.2019.117147. Epub 2019 Dec 9. PMID: 31830480. [Content Brief] [3]. Feng Q, et al. Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. Molecules. 2016 Apr 22 21(4):534. [4]. Wu KX, et al. The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses. Acta Pharm Sin B. 2023 May 13(5):2039-2055.
Last Update	2025-04-01 14:45:47

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