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| Supplier Name | MedChemExpress (MCE) |
| Contact | sales |
| Tel | 609-228-6898 |
| Mobile | 609-228-6898 |
| sales@medchemexpress.com; tech@medchemexpress.com | |
| Website | https://www.medchemexpress.com/ |
| Product Name | Denosumab |
| Synonyms | Denosumab |
| CAS | 615258-40-7 |
| EINECS | |
| Chemical Formula | |
| Molecular Weight | |
| inchi | |
| Package | 1 mg;5 mg;10 mg |
| Price | Email to quote |
| Descriptions | Denosumab (anti-TNFSF11) MedChemExpress (MCE) HY-P9958A 95.00% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies. Denosumab (0.25-20 μM, 7 days) enhances osteogenic differentiation at physiological concentrations in human mesenchymal stem cells of the jaw bone[4]. Denosumab (0.1 μM–5 μM) alleviates ROS-induced chondrocytes Apoptosis, with promoting Bcl-2 and suppressing pro-apoptotic genes Bax and caspase-3[5]. Denosumab (5 μM, 5-60 min) suppresses RANKL-induced osteoclastogenesis by inhibiting the NF-κB signaling pathway[5]. Denosumab (0.001-0.1 μg/mL, 24-72 h) significantly increases human β-cell proliferation[6]. Denosumab (10 mg/kg, s.c., twice a week for 4 weeks) ameliorates pain-related behaviors and osteoarthritis (OA) progression in the OA mouse model[5]. Denosumab (1 mg/kg, s.c., single) enhances human β-cell proliferation in human islets transplanted under the kidney capsule of male euglycemic NOD/SCID mice[6]. Denosumab (5 mg/kg, s.c., single) increases testis weight, inhibin B, and sperm count in humanized RANKL mice[7]. Human Human IgG2 kappa Human IgG2 kappa, Isotype Control [1]. 1. |
| Last Update | 2025-04-01 14:45:47 |
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